Evidence map›Paper›PMID 34402430›Full record

ArticleeLife2021

Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA.

Ki-Sun Park, Beenish Rahat, Hyung Chul Lee, Zu-Xi Yu, Jacob Noeker, Apratim Mitra, Connor M Kean, Russell H Knutsen, Danielle Springer, Claudia M Gebert and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Clinical,medRxiv : the preprint server for health sciences · 2026
    Article
  4. H19 and IGF2 imprinting from embryogenesis to oncogenesis.Frontiers in cell and developmental biology · 2026
    Review
  5. Article
  6. Article
  7. Imprinted Long Non-Coding RNAs in Mammalian Development and Disease.International journal of molecular sciences · 2023
    Review
  8. Long noncoding RNA (lncRNA)Genes & diseases · 2023
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ki-Sun Park *Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.ORCID 0000-0003-1322-767X
Beenish Rahat *Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.ORCID 0000-0003-0371-2356
Hyung Chul LeeDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Zu-Xi YuPathology Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, United States.
Jacob NoekerDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.ORCID 0000-0002-4344-3114
Apratim MitraDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Connor M KeanDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Russell H KnutsenLaboratory of Vascular and Matrix Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, United States.ORCID 0000-0001-6761-6502
Danielle SpringerMurine Phenotyping Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, United States.ORCID 0000-0002-6261-9744
Claudia M GebertDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.ORCID 0000-0002-1282-1602
Beth A KozelLaboratory of Vascular and Matrix Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, United States.ORCID 0000-0002-9757-7118
Karl PfeiferDivision of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.ORCID 0000-0002-0254-682X
National Institutes of Health · US

Funding

Regulated expression and developmental functions of the H19 long noncoding RNAZIAHD001804 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PFEIFER, KARL ERIC · 2009 to 2025
$20.2M
Murine Phenotyping CoreZIGHL006190 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SPRINGER, DANIELLE · 2014 to 2025
$15.2M
Novel Techniques for Vascular Investigation ZIAHL006247 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KOZEL, BETH · 2020 to 2022
$739k
Intramural NIH HHS ZIA HD001804Intramural NIH HHS ZIA HL006247
6 · The paper itself

Abstract

Maternal loss of imprinting (LOI) at the

Indexed as

AnimalsBeckwith-Wiedemann SyndromeCardiomyopathiesCardiovascular SystemCell DifferentiationDisease Models, AnimalEndothelial CellsInsulin-Like Growth Factor IIMiceMice, Inbred C57BLMicroRNAsMyocytes, CardiacPhenotypeRNA, Long NoncodingSignal TransductionH19 long non-coding RNAIGF2 protein, mouseInsulin-Like Growth Factor IIMicroRNAsmirnlet7 microRNA, mouseRNA, Long Noncodingbeckwith wiedemann syndromedevelopmental biologyepigeneticsgeneticsgenomic imprintinggenomicsH19 lncRNAheartIGF2mouse

Identifiers

PMID34402430
PMCPMC8425947
OpenAlexW3195792108

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.