ArticleeLife2021
KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Circulating factors induced by time-restricted eating drive metabolic reprogramming in endothelial cells.GeroScience · 2026Article
- Klf10 Regulates the Emergence of Glial Phenotypes During Hypothalamic Development.Journal of neuroscience research · 2025Article
- Krüppel-like factor 10 protects against metabolic dysfunction-associated steatohepatitis by regulating HNF4α-mediated metabolic pathways.Metabolism: clinical and experimental · 2024Article
- New Insights into the Role of KLF10 in Tissue Fibrosis.International journal of molecular sciences · 2024Review
- Single-cell analysis of human prepuce reveals dynamic changes in gene regulation and cellular communications.BMC genomics · 2023Article
- Brain Gene Expression of Foraging Behavior and Social Environment in Ceratina calcarata.Genome biology and evolution · 2023Article
- Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes.Genes & diseases · 2023Review
- CD36 regulates diurnal glucose metabolism and hepatic clock to maintain glucose homeostasis in mice.iScience · 2023Article
- Specificity Proteins (SP) and Krüppel-like Factors (KLF) in Liver Physiology and Pathology.International journal of molecular sciences · 2023Review
- Day-night and seasonal variation of human gene expression across tissues.PLoS biology · 2023Article
- The circadian rhythm: an influential soundtrack in the diabetes story.Frontiers in endocrinology · 2023Review
- Serum and Soleus Metabolomics Signature ofMetabolites · 2022Article
- USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation.Nucleic acids research · 2022Article
- KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7.EMBO reports · 2022Article
- Deciphering the Role ofJournal of biomedical science and engineering · 2022Article
- Characterization of Accessible Chromatin Regions in Cattle Rumen Epithelial Tissue during Weaning.Genes · 2022Article
- Day-night and seasonal variation of human gene expression across tissues.bioRxiv : the preprint server for biology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian circadian timing system and metabolism are highly interconnected, and disruption of this coupling is associated with negative health outcomes. Krüppel-like factors (KLFs) are transcription factors that govern metabolic homeostasis in various organs. Many KLFs show a circadian expression in the liver. Here, we show that the loss of the clock-controlled KLF10 in hepatocytes results in extensive reprogramming of the mouse liver circadian transcriptome, which in turn alters the temporal coordination of pathways associated with energy metabolism. We also show that glucose and fructose induce
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