Evidence map›Paper›PMID 34402378›Full record

ArticleRenal failure2021

Dimethyl fumarate ameliorates endotoxin-induced acute kidney injury against macrophage oxidative stress.

Kejun Zhou, Mengyi Xie, Shuli Yi, Yun Tang, Haojun Luo, Qiong Xiao, Jun Xiao, Yi Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kejun ZhouDepartment of Pediatric Surgery, Hepatobiliary Research Institute, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Mengyi XieHepatobiliary Research Institute, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Shuli YiDepartment of Nephrology, Clinical Research Center of Kidney Disease in Sichuan Province, Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, Medicine of School, University of Electronic Science and Technology of China, Chengdu, China.
Yun TangDepartment of Nephrology, Clinical Research Center of Kidney Disease in Sichuan Province, Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, Medicine of School, University of Electronic Science and Technology of China, Chengdu, China.
Haojun LuoDepartment of Nephrology, Clinical Research Center of Kidney Disease in Sichuan Province, Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, Medicine of School, University of Electronic Science and Technology of China, Chengdu, China.
Qiong XiaoDepartment of Nephrology, Clinical Research Center of Kidney Disease in Sichuan Province, Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, Medicine of School, University of Electronic Science and Technology of China, Chengdu, China.
Jun XiaoDepartment of Cardiovascular Medicine, Chongqing University Center Hospital, Chongqing, China.
Yi LiDepartment of Nephrology, Clinical Research Center of Kidney Disease in Sichuan Province, Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, Medicine of School, University of Electronic Science and Technology of China, Chengdu, China.
University of Electronic Science and Technology of China · CNAffiliated Hospital of North Sichuan Medical College · CNChongqing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCharacterized by macrophage infiltration, renal inflammation during septic acute kidney injury (AKI) reveals a ubiquitous human health problem. Unfortunately, effective therapies with limited side effects are still lacking. This study is aiming to elucidate the role of Dimethyl fumarate (DMF) in macrophages against oxidative stress of septic AKI.

methodsBalb/c mice were gavaged by 50 mg/kg DMF then injected with 10 mg/kg LPS by

resultsDMF ameliorated murine LPS nephritis with reduced blood urea nitrogen and serum creatinine, as well as decreased the histological alterations compared to the normal control. DMF significantly inhibited the expression of iNOS and reduced the production of nitrite in Raw264.7 cells following LPS treatment. Our study also revealed the role of DMF in protecting against intracellular ROS accumulation and mitochondria dysfunction in LPS-induced nephritis. DMF facilitated colocalization and interaction between Sirt1 and Nrf-2 in LPS-treated cells.

conclusionsThis study showed that DMF alleviated LPS-induced nephritis, indicating protective effects of DMF on macrophage against oxidative stress induced by LPS potentially involving Nrf-2-mediated pathway.

Indexed as

Acute Kidney InjuryAnimalsCreatinineDimethyl FumarateEndotoxinsFemaleKidneyLipopolysaccharidesMacrophagesMiceMice, Inbred BALB CMitochondriaNF-E2-Related Factor 2Oxidative StressProtective AgentsRAW 264.7 CellsCreatinineDimethyl FumarateEndotoxinsLipopolysaccharidesNF-E2-Related Factor 2Protective AgentsSirtuin 1acute kidney injuryDimethyl fumaratemacrophageoxidative stress

Identifiers

PMID34402378
PMCPMC8381931
OpenAlexW3194268722

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.