Evidence map›Paper›PMID 34402362›Full record

ArticleExpert review of clinical pharmacology2021

Edoxaban for the treatment of pulmonary embolism in hospitalized COVID-19 patients.

Valerio Langella, Roberta Bottino, Antonio Asti, Giulio Maresca, Gisella Di Palma, Domenico Pomponi, Claudia Sassone, Egidio Imbalzano, Vincenzo Russo

Open access · greenAbstract read
In one paragraph

Article in Expert review of clinical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Valerio LangellaInternal Medicine Unit - COVID19 Emergency Department, S. Maria Di Loreto Nuovo Hospital, Naples, Italy.
Roberta BottinoCardiology Unit, Department Of Translational Medical Sciences, University of Campania "Luigi Vanvitelli," Monaldi Hospital, Naples, Italy.ORCID 0000-0002-2938-4728
Antonio AstiInternal Medicine Unit - COVID19 Emergency Department, S. Maria Di Loreto Nuovo Hospital, Naples, Italy.
Giulio MarescaInternal Medicine Unit - COVID19 Emergency Department, S. Maria Di Loreto Nuovo Hospital, Naples, Italy.
Gisella Di PalmaInternal Medicine Unit - COVID19 Emergency Department, S. Maria Di Loreto Nuovo Hospital, Naples, Italy.
Domenico PomponiInternal Medicine Unit - COVID19 Emergency Department, S. Maria Di Loreto Nuovo Hospital, Naples, Italy.
Claudia SassoneAnesthesiology, Intensive Care And Pain Treatment Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Egidio ImbalzanoDepartment Of Clinical And Experimental Medicine, University Of Messina, Messina, Italy.
Vincenzo RussoCardiology Unit, Department Of Translational Medical Sciences, University of Campania "Luigi Vanvitelli," Monaldi Hospital, Naples, Italy.
Ospedale Santa Maria di Loreto Nuovo · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to investigate the clinical performance of edoxaban for the treatment of pulmonary embolism (PE) in hospitalized COVID-19 patients.

methodsWe conducted a retrospective analysis selecting hospitalized patients with COVID-19 admitted to our Institution from 20 May 2020 to 20 November 2020 with computer tomography (CT) detected PE at admission, treated with edoxaban after initial parenteral therapy. Clinical outcomes were compared between patients with and without ARDS at admission and between those with and without CT confirmed PE resolution.

results50 patients were included. Mean follow-up was 42.5 ± 10 days. No baseline differences were found between patients with ARDS (30%) and those without ARDS at admission. Patients with PE resolution (84%) were younger (

conclusionEdoxaban was an effective and safe treatment for acute PE in COVID-19 setting.

Indexed as

SARS-CoV-2AdultAgedCOVID-19Factor Xa InhibitorsFemaleFondaparinuxHumansMaleMiddle AgedMultivariate AnalysisProportional Hazards ModelsPulmonary EmbolismPyridinesRespiratory Distress SyndromeRetrospective StudiesedoxabanFactor Xa InhibitorsFondaparinuxPyridinesThiazolesARDSCOVID-19edoxabanefficacypulmonary embolismsafetySARS-CoV-2

Identifiers

PMID34402362
PMCPMC8425471
OpenAlexW3195971127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.