ArticleAddiction biology2022
The relation between cannabis use, dependence severity and white matter microstructure: A diffusion tensor imaging study.
Article in Addiction biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Measuring white matter microstructure in 1,457 cannabis users and 1,441 controls: A systematic review of diffusion-weighted MRI studies.Frontiers in neuroimaging · 2023Pooled it
- No differences in inhibitory control or prefrontal activation during a cannabis cue stop-signal task across CUDIT-R-defined CUD-risk groups.Psychopharmacology · 2026Article
- Cumulative exposure to cannabis and hippocampus MRI in middle age: results from the coronary artery risk development in young adults (CARDIA) study.Translational psychiatry · 2026Article
- What Do Thirty Years of Neuroimaging Research Tell Us About Recreational Cannabis Use and Brain Integrity? A Narrative Review of the Multimodal Neuroimaging Evidence to Date.Substance abuse and rehabilitation · 2026Review
- The relationship between recreational cannabis use, psychotic-like experiences, and the salience network in adolescent and young adult twins.Psychological medicine · 2025Article
- Cannabis use in adolescence and young adulthood and its effects on brain structure and function: a scoping review.Frontiers in psychiatry · 2025Review
- Chronic cannabis use associated with subcortical topological reorganization of structural connectivity in adults.Drug and alcohol dependence · 2024Article
- Adolescent substance use initiation and long-term neurobiological outcomes: insights, challenges and opportunities.Molecular psychiatry · 2024Review
- The First "Hit" to the Endocannabinoid System? Associations Between Prenatal Cannabis Exposure and Frontolimbic White Matter Pathways in Children.Biological psychiatry global open science · 2024Article
- [Cannabis use in adolescents : Narrative Review and Position paper of the "Addiction Disorders in Adolescents" task force of the Austrian Society for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy (ÖGKJP)].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2023Review
- Enhancing axonal myelination in seniors: A review exploring the potential impact cannabis has on myelination in the aged brain.Frontiers in aging neuroscience · 2023Review
- The relation between cannabis use, dependence severity and white matter microstructure: A diffusion tensor imaging study.Addiction biology · 2022Article
Corrections and comments
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Despite the significant societal and personal burden of cannabis use, the impact of long-term use and Cannabis Use Disorder (CUD) on white matter microstructure is still unclear. Previous studies show inconsistent findings, in part due to heterogeneity in methodology, variable severity of cannabis use, and potential confounding effects of other mental health issues and substance use. The goal of this diffusion tensor imaging (DTI) study was to compare whole-brain white matter microstructure between 39 near daily cannabis users and 28 controls closely matched on age, sex, alcohol use, cigarette use and mental health. Within the group of cannabis users, associations between white matter microstructure and recent cannabis use, dependence severity, and age of onset and duration of weekly use were investigated. White matter microstructure did not differ between cannabis users and controls and did not covary with recent cannabis use, dependence severity, or duration of use. Earlier onset of weekly cannabis use was related to lower fractional anisotropy (FA) in various sections of the right inferior longitudinal fasciculus and uncinate fasciculus. These findings suggest that long-term near-daily cannabis use does not necessarily affect white matter microstructure, but vulnerability may be higher during adolescence. These findings underscore the importance of sample composition and warrant further studies that investigate the moderating role of age of onset in the impact of cannabis on the brain.
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