Evidence map›Paper›PMID 34402053›Full record

ReviewDevelopmental medicine and child neurology2022

Is the search for cerebral palsy 'cures' a reasonable and appropriate goal in the 2020s?

Ingrid Honan, Megan Finch-Edmondson, Christine Imms, Iona Novak, Amy Hogan, Shannon Clough, Bruce Bonyhady, Sarah McIntyre, Catherine Elliott, Shirley Wong and 2 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Developmental medicine and child neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Inhibitory Synaptic Influences on Developmental Motor Disorders.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Ingrid HonanCerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-8803-8094
Megan Finch-EdmondsonCerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-9628-5842
Christine ImmsDepartment of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-9055-3554
Iona NovakCerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-6001-4867
Amy HoganCerebral Palsy Society of New Zealand, Auckland, New Zealand.
Shannon CloughMember or family member with lived experience of cerebral palsy, The Australian and New Zealand Cerebral Palsy Strategy, Sydney, New South Wales, Australia.
Bruce BonyhadyMelbourne Disability Institute, The University of Melbourne, Melbourne, Victoria, Australia.
Sarah McIntyreCerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-0234-1541
Catherine ElliottSchool of Occupational Therapy, Social Work and Speech Pathology, Curtin University, Bentley, Western Australia, Australia.
Shirley WongMember or family member with lived experience of cerebral palsy, The Australian and New Zealand Cerebral Palsy Strategy, Sydney, New South Wales, Australia.
Michael BinkCerebral Palsy Australia, Sydney, New South Wales, Australia.
Nadia BadawiCerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
The University of Sydney · AUCerebral Palsy Alliance · AUThe University of Melbourne · AUThe Kids Research Institute Australia · AUUnited Cerebral Palsy · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the field of disability research and advocacy, the notion of 'cures' is contentious. Cerebral palsy (CP) is no exception. In this narrative review, we combine perspectives gained during community consultation undertaken for the Australian and New Zealand Cerebral Palsy Strategy, 2020 with those published in the scientific and grey literature to understand whether 'cures for CP' is a reasonable and appropriate goal. We frame these perspectives through the lens of several ethical principles central to the discussion. These include maintaining hope while also being realistic, sensitivity to sharply different viewpoints amongst people with disability and their families, and responding to community priorities, societal attitudes, and identity. Through this exploration of the literature and perspectives, we arrived at a definition of 'cures for CP' that is pluralized and focuses on functional improvement and/or symptom reduction whilst still acknowledging the potential for neural repair/regeneration strategies.

Indexed as

GoalsResearchAustraliaCerebral PalsyHumansNew Zealand

Identifiers

PMID34402053
PMCPMC9290932
OpenAlexW3195179476

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.