Evidence map›Paper›PMID 34402052›Full record

ArticleBritish journal of haematology2021

Longitudinal study of glomerular hyperfiltration and normalization of estimated glomerular filtration in adults with sickle cell disease.

Vimal K Derebail, Qingning Zhou, Emily J Ciccone, Jianwen Cai, Kenneth I Ataga

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in British journal of haematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Management of Kidney Disease with Sickle Cell Disease.Journal of the American Society of Nephrology : JASN · 2025
    Review
  5. Article
  6. Sickle Cell Disease and CKD: An Update.American journal of nephrology · 2024
    Review
  7. Glomerular hyperfiltration: part 2-clinical significance in children.Pediatric nephrology (Berlin, Germany) · 2023
    Review
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Vimal K DerebailDivision of Nephrology and Hypertension, UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-7662-7497
Qingning ZhouDepartment of Mathematics and Statistics, University of North Carolina at Charlotte, Charlotte, NC, USA.
Emily J CicconeDivision of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jianwen CaiDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.
Kenneth I AtagaCenter for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID 0000-0002-4501-9982
University of North Carolina at Chapel Hill · USUniversity of North Carolina at Charlotte · USUniversity of Tennessee Health Science Center · US

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
Endothelial Dysfunction in the Pathogenesis of Sickle Cell NephropathyR01HL111659 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARCHER, DAVID R, ATAGA, KENNETH I · 2012 to 2016
$2.3M
THE ASSOCIATION OF BIOMARKERS OF ENDOTHELIAL FUNCTION WITH PROSPECTIVE CHANGES IN KIDNEY FUNCTION IN SICKLE CELL ANEMIAR01FD006030 · FDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ATAGA, KENNETH I · 2017 to 2021
$2.0M
FDA HHS R01 FD006030NCATS NIH HHS UL1 TR001111NCATS NIH HHS UL1 TR002489NHLBI NIH HHS R01 HL111659
6 · The paper itself

Abstract

Glomerular hyperfiltration is common in sickle cell disease (SCD) and precedes proteinuria and declining kidney function. We evaluated hyperfiltration in SCD patients and its "normalization." Routine visit data were collected retrospectively from adult SCD patients in a single centre from 2004 to 2013. Baseline was defined as first available serum creatinine and hyperfiltration as estimated glomerular filtration rates (eGFR) >130 ml/min/1·73 m

Indexed as

Glomerular Filtration RateAdultAnemia, Sickle CellAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersAntihypertensive Agentsbeta-ThalassemiaCreatinineFemaleFollow-Up StudiesHumansHypertensionKaplan-Meier EstimateKidneyKidney DiseasesMaleAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersAntihypertensive AgentsCreatinineestimated glomerular filtration ratehaemoglobinhyperfiltrationproteinuriasickle cell disease

Identifiers

PMID34402052
PMCPMC8478807
OpenAlexW3195743062

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.