ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2021
"Waste Not, Want Not" - Leveraging Sewer Systems and Wastewater-Based Epidemiology for Drug Use Trends and Pharmaceutical Monitoring.
Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Wastewater-based epidemiology to enhance public health preparedness and response during large-scale events: experiences from the 2024 Republican and Democratic National Conventions - Milwaukee, WI and Chicago, IL.Frontiers in public health · 2026Article
- Piloting wastewater-based monitoring on a university campus to inform public health surveillance and response for opioids and other high-risk substances.Journal of water and health · 2026Article
- Use of Illegally Manufactured Fentanyl in the United States: Current Trends.Current addiction reports · 2025Article
- Communicating wastewater-based surveillance data to drive action.Journal of water and health · 2025Review
- Advancing health equity in wastewater-based epidemiology: A global critical review and conceptual framework.SSM - population health · 2025Review
- Fentanyl, Heroin, Methamphetamine, and Cocaine Analyte Concentrations in Urine Drug Testing Specimens.JAMA network open · 2024Article
- Submersible voltammetric sensing probe for rapid and extended remote monitoring of opioids in community water systems.Mikrochimica acta · 2024Article
- Wastewater Surveillance for Xylazine in Kentucky.AJPM focus · 2024Article
- Optimisation of analytical methods for tuberculosis drug detection in wastewater: A multinational study.Heliyon · 2024Article
- Changes to Public Health Surveillance Methods Due to the COVID-19 Pandemic: Scoping Review.JMIR public health and surveillance · 2024Article
- Stakeholder Interviews to Inform Best Practice for Public Facing COVID-19 Wastewater Dashboards.Gates open research · 2024Article
- Analysis of Wastewater Samples to Explore Community Substance Use in the United States: Pilot Correlative and Machine Learning Study.JMIR formative research · 2023Article
- Drug consumption in German cities and municipalities during the COVID-19 lockdown: a wastewater analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Utilizing a National Wastewater Monitoring Program to Address the U.S. Opioid Epidemic: A Focus on Metro Atlanta, Georgia.International journal of environmental research and public health · 2023Review
- Recent Advances in the Development of Portable Electrochemical Sensors for Controlled Substances.Sensors (Basel, Switzerland) · 2023Review
- Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota.Nature reviews. Microbiology · 2022Review
- The role of massive demographic databases in intractable illnesses: Denomics for dementia.AIMS public health · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
During the current global COVID-19 pandemic and opioid epidemic, wastewater-based epidemiology (WBE) has emerged as a powerful tool for monitoring public health trends by analysis of biomarkers including drugs, chemicals, and pathogens. Wastewater surveillance downstream at wastewater treatment plants provides large-scale population and regional-scale aggregation while upstream surveillance monitors locations at the neighborhood level with more precise geographic analysis. WBE can provide insights into dynamic drug consumption trends as well as environmental and toxicological contaminants. Applications of WBE include monitoring policy changes with cannabinoid legalization, tracking emerging illicit drugs, and early warning systems for potent fentanyl analogues along with the resurging wave of stimulants (e.g., methamphetamine, cocaine). Beyond drug consumption, WBE can also be used to monitor pharmaceuticals and their metabolites, including antidepressants and antipsychotics. In this manuscript, we describe the basic tenets and techniques of WBE, review its current application among drugs of abuse, and propose methods to scale and develop both monitoring and early warning systems with respect to measurement of illicit drugs and pharmaceuticals. We propose new frontiers in toxicological research with wastewater surveillance including assessment of medication assisted treatment of opioid use disorder (e.g., buprenorphine, methadone) in the context of other social burdens like COVID-19 disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.