ArticleInternational journal of implant dentistry2021
Glycemic fluctuation exacerbates inflammation and bone loss and alters microbiota profile around implants in diabetic mice with experimental peri-implantitis.
Article in International journal of implant dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Diabetes exacerbates experimental peri-implantitis in mice with elevated IL-17A-associated inflammation and IL-17F upregulation.Scientific reports · 2026Article
- Impaired Mitophagy-Induced Apoptosis of Gingival Fibroblasts Exacerbates Diabetic Periodontitis Via THBS-1/CD36-Dependent Macrophage Activation.Inflammation · 2026Article
- SGLT2 inhibition, uric acid and inflammation in glycemic burden-related progression of cardiac autonomic neuropathy in type 2 diabetes mellitus: insights from machine learning and mediation analysis.Frontiers in endocrinology · 2026Article
- Hyperglycemia and systemic inflammation differentially shape immune dysregulation, tissue destruction, and microbiota in experimental periodontitis and peri-implantitis in diabetic mice.Frontiers in immunology · 2026Article
- Advances in oral disease models: a mini-review of developments from 2015 to 2025.Frontiers in dental medicine · 2026Review
- Biomaterial regulation of excessive inflammation restores osteoimmune homeostasis in diabetic bone regeneration.Regenerative biomaterials · 2026Review
- Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes.World journal of diabetes · 2025Article
- Analysis of the correlation between glycemic variability indices and disease severity as well as inflammatory status in patients with type 2 diabetes mellitus and periodontitis.Clinical oral investigations · 2025Article
- Glycemic Control and Implant Stability in Patients with Type II Diabetes: Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- Correlation Between Blood Glucose Fluctuations and Osteoporosis in Type 2 Diabetes Mellitus.International journal of endocrinology · 2025Review
- A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes.International journal of oral science · 2024Article
- Sustained Release of Salicylic Acid for Halting Peri-Implantitis Progression in Healthy and Hyperglycemic Systemic Conditions: A Gottingen Minipig Model.ACS biomaterials science & engineering · 2024Article
- [Research Progress in the Molecular Regulatory Mechanisms of Alveolar Bone Restoration].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population.Journal of oral microbiology · 2024Article
- Review
- PF127 Hydrogel-Based Delivery of Exosomal CTNNB1 from Mesenchymal Stem Cells Induces Osteogenic Differentiation during the Repair of Alveolar Bone Defects.Nanomaterials (Basel, Switzerland) · 2023Article
- Review
- Rodent peri-implantitis models: a systematic review and meta-analysis of morphological changes.Journal of periodontal & implant science · 2022Article
- CCK regulates osteogenic differentiation through TNFα/NF-κB in peri-implantitis.The Journal of international medical research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe impact of glycemic fluctuation under diabetic condition on peri-implantitis in diabetic patients remains unclear. We hypothesized that glycemic fluctuation has greater adverse effect on experimental peri-implantitis, compared with sustained high blood glucose in diabetes.
resultsMaxillary left first and second molars of diabetic db/db mice were extracted and were replaced with one dental implant in the healed edentulous space. Glycemic control or fluctuation were managed by constant or interrupted oral administration of rosiglitazone to these mice. Meanwhile, experimental peri-implantitis was induced by ligation around implants. After 14 weeks, inflammatory responses, and peri-implant bone loss, together with oral microbiota profile were analyzed. Diabetic mice with glycemic fluctuation showed greater peri-implant bone loss, inflammatory cell infiltration, and osteoclastogenesis, compared with mice with sustained hyperglycemia. Compared to sustained hyperglycemia, glycemic fluctuation led to further increase in IL-1β, TNFα, RANKL, TLR2/4, IRAK1, and TRAF6 mRNA expression in peri-implant gingival tissues. Both rosiglitazone-induced glycemic control and glycemic fluctuation caused microbiota profile change in diabetic mice compared to that in uncontrolled hyperglycemic mice.
conclusionsThis study suggests that glycemic fluctuation may aggravate peri-implantitis inflammation and bone loss, which may be associated with a shift in peri-implant microbial profile towards dysbiotic changes and the activation of TLR2/4-IRAK1-TRAF6 signaling.
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