Evidence map›Paper›PMID 34401981›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

The relationship between emotional well-being and understanding of prognosis in patients with acute myeloid leukemia (AML).

Anmol Singh, Susan C Locke, Steven P Wolf, Tara A Albrecht, Jesse D Troy, Heather Derry, Areej El-Jawahri, Thomas W LeBlanc

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
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  4. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Anmol SinghDepartment of Medicine, Duke University School of Medicine, Durham, NC, 27710, USA.
Susan C LockeDuke Cancer Institute, Durham, NC, 27710, USA.
Steven P WolfDuke Cancer Institute, Durham, NC, 27710, USA.
Tara A AlbrechtDuke University School of Nursing, Duke University, Durham, NC, 27710, USA.
Jesse D TroyDuke Cancer Institute, Durham, NC, 27710, USA.
Heather DerryWeill Cornell Medical College, New York, NY, 10065, USA.
Areej El-JawahriDepartment of Hematology and Oncology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Thomas W LeBlancDepartment of Medicine, Duke University School of Medicine, Durham, NC, 27710, USA. thomas.leblanc@duke.edu.ORCID http://orcid.org/0000-0002-0546-7895

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAdults with acute myeloid leukemia (AML) face considerable distress and often have a poor prognosis. However, little is known about these patients' perceptions of prognosis and how this relates to emotional well-being (EWB).

methodsWe conducted a prospective, observational study of 50 adult patients with AML initiating chemotherapy, and surveyed them longitudinally for 6 months about their prognosis, treatment goals, quality of life, and EWB (by FACT-G). We derived a prognostic estimate for each patient based on data from published trials summarized in National Comprehensive Care Network Guidelines. We used descriptive statistics and longitudinal modeling to test the hypothesis that more accurate prognostic awareness is associated with worse EWB.

resultsMost patients (n = 43; 86%) had an objectively poor prognosis attributable to relapsed disease, complex karyotype, or FLT3 mutation. Yet, 74% of patients reported expecting a 50% or greater chance of cure. Patients with a poor prognosis more often had discordant prognostic estimates, compared to those with favorable risk AML (OR = 7.25, 95% CI 1.21, 43.37). Patient-reported prognostic estimates did not vary significantly over time. At baseline, patients who better understood their prognosis had worse EWB and overall quality-of-life scores (EWB 12 vs. 19.5; p = 0.01; FACT-G 65 vs. 75.5; p = 0.01).

conclusionPatients with AML overestimate their prognosis, and awareness of a poor prognosis is associated with worse emotional well-being. Efforts are needed to improve patients' understanding of their prognosis, and to provide more psychosocial support and attention to well-being as part of high-quality leukemia care.

Indexed as

Leukemia, Myeloid, AcuteQuality of LifeAdultHumansMutationPrognosisProspective StudiesAcute myeloid leukemiaDistressEmotional well-beingPrognosisPrognostic understanding

Identifiers

PMID34401981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.