Evidence map›Paper›PMID 34401744›Full record

ArticleToxicon: X2021

Addressing the global snakebite crisis with geo-spatial analyses - Recent advances and future direction.

Anna F V Pintor, Nicolas Ray, Joshua Longbottom, Carlos A Bravo-Vega, Masoud Yousefi, Kris A Murray, Dileepa S Ediriweera, Peter J Diggle

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Toxicon: X, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06808789 (Mapping Snakebite Risk in Ghana and Rwanda), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06808789 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Mapping Snakebite Risk in Ghana and Rwanda: Using Primary Data Collection and Geostatistical Techniques to Develop an Approach to Risk Estimation for Snakebite

TypeobservationalSponsorLiverpool School of Tropical MedicineRan2025 to 2026Enrolled32,000ConditionsSnakebite, Snake Envenomation
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. A systematic review of variables associated with snakebite risk in spatial and temporal analyses.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025
    Pooled it
  3. Article
  4. Article
  5. Article
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  7. Article
  8. Article
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  10. Utilising snake rescue data to understand snake-human conflict in Hooghly, West Bengal, India.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025
    Article
  11. Article
  12. Article
  13. The incidence of snakebite in South Africa and the challenges associated with lack of reporting.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025
    Article
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  16. Review
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  18. A database on the historical and current occurrences of snakes in Eswatini.Database : the journal of biological databases and curation · 2025
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 7 countries.

Anna F V PintorDivision of Data, Analytics and Delivery for Impact (DDI), World Health Organization, Geneva, Switzerland.
Nicolas RayGeoHealth Group, Institute of Global Health, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Joshua LongbottomDepartment of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Carlos A Bravo-VegaResearch Group in Mathematical and Computational Biology (BIOMAC), Department of Biomedical Engineering, University of Los Andes, Bogotá, Colombia.
Masoud YousefiSchool of Biology, College of Science, University of Tehran, Iran.
Kris A MurrayMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, UK.
Dileepa S EdiriweeraHealth Data Science Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Peter J DiggleDepartment of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Liverpool School of Tropical Medicine · GBAustralian Institute of Tropical Health and Medicine · AUMRC Unit the Gambia · GMUniversidad de Los Andes · COUniversity of Geneva · CHUniversity of Kelaniya · LKUniversity of Tehran · IR

Funding

Medical Research Council MR/R015600/1World Health Organization 001
6 · The paper itself

Abstract

Venomous snakebite is a neglected tropical disease that annually leads to hundreds of thousands of deaths or long-term physical and mental ailments across the developing world. Insufficient data on spatial variation in snakebite risk, incidence, human vulnerability, and accessibility of medical treatment contribute substantially to ineffective on-ground management. There is an urgent need to collect data, fill knowledge gaps and address on-ground management problems. The use of novel, and transdisciplinary approaches that take advantage of recent advances in spatio-temporal models, 'big data', high performance computing, and fine-scale spatial information can add value to snakebite management by strategically improving our understanding and mitigation capacity of snakebite. We review the background and recent advances on the topic of snakebite related geospatial analyses and suggest avenues for priority research that will have practical on-ground applications for snakebite management and mitigation. These include streamlined, targeted data collection on snake distributions, snakebites, envenomings, venom composition, health infrastructure, and antivenom accessibility along with fine-scale models of spatio-temporal variation in snakebite risk and incidence, intraspecific venom variation, and environmental change modifying human exposure. These measures could improve and 'future-proof' antivenom production methods, antivenom distribution and stockpiling systems, and human-wildlife conflict management practices, while simultaneously feeding into research on venom evolution, snake taxonomy, ecology, biogeography, and conservation.

Indexed as

EnvenomingsMedically relevant snakesNeglected tropical diseasesSnakebite incidenceSpatio-temporal epidemiologySpecies distribution models

Identifiers

PMID34401744
PMCPMC8350508
OpenAlexW3193125362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.