Evidence map›Paper›PMID 34401678›Full record

ArticleiScience2021

Use of dual-electron probes reveals the role of ferritin as an iron depot in

Maria A Aronova, Seung-Jae Noh, Guofeng Zhang, Colleen Byrnes, Emily Riehm Meier, Young C Kim, Richard D Leapman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Outline of Iron Metabolism, with Emphasis on Erythroid Cells.Mediterranean journal of hematology and infectious diseases · 2025
    Review
  4. Mechanisms controlling cellular and systemic iron homeostasis.Nature reviews. Molecular cell biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Maria A AronovaLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USA.
Seung-Jae NohPenta Medix Co., Ltd., Seongnam, Gyeonggi-do, Republic of Korea.
Guofeng ZhangLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USA.
Colleen ByrnesNational Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Emily Riehm MeierIndiana Hemophilia and Thrombosis Center, Indianapolis, IN, USA.
Young C KimComputational Biophysics, Center for Materials Physics and Technology, US Naval Research Laboratory, Washington, DC, USA.
Richard D LeapmanLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USA.
National Institute of Biomedical Imaging and Bioengineering · USIndiana Hemophilia and Thrombosis Center · USNational Institute of Diabetes and Digestive and Kidney Diseases · USUnited States Naval Research Laboratory · US

Funding

Energy-Filtered Electron TomographyZIAEB000037 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI LEAPMAN, RICHARD · 2009 to 2022
$4.2M
6 · The paper itself

Abstract

In the finely regulated process of mammalian erythropoiesis, the path of the labile iron pool into mitochondria for heme production is not well understood. Existing models for erythropoiesis do not include a central role for the ubiquitous iron storage protein ferritin; one model proposes that incoming endosomal Fe

Indexed as

BiochemistryBiological sciencesCell biologyTechnical aspects of cell biology

Identifiers

PMID34401678
PMCPMC8355919
OpenAlexW3185523187

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.