ArticleContemporary clinical trials communications2021
Barriers and facilitators to the participation of subjects in clinical trials: An overview of reviews.
Article in Contemporary clinical trials communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Total energy expenditure measured using doubly labeled water in adults with major chronic diseases: a systematic review.The American journal of clinical nutrition · 2024Pooled it
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- Exploring a Facilitator-Enabled Flexible iSupport for Dementia Program: An Internal Pilot Mixed-Methods Study.Nursing open · 2026Trial
- Effective and cost-effective strategies for recruiting rural adults into a civic engagement and health behavior change research study.BMC public health · 2026Trial
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- Trial
- Comparison of remote to hybrid methods on recruitment and retention rates in a smoking cessation trial.Drug and alcohol dependence · 2026Trial
- PROGRESS: A patient-centered engagement infrastructure and multi-level approach to enrich diversity, equity, and inclusion in a national randomized online behavioral pain treatment study.The journal of pain · 2025Trial
- A pilot feasibility randomised controlled trial of bone antiresorptive agents on bone turnover markers in critically ill women.Scientific reports · 2024Trial
- Precision Recruitment and Engagement of Individuals at Risk for Diabetes and Hypertension in Clinical Trials (PREDHICT): A Randomized Trial for an E-Persuasive Mobile Application to Inform Decision Making about Clinical Trials.International journal of environmental research and public health · 2023Trial
- Recruitment to a trial of antipsychotic reduction: impact of an acceptability study.BMC medical research methodology · 2023Trial
- A Qualitative Study Exploring the Acceptability of Taking Part in a Large Multicentre RCT of Medication for Anxiety in Autistic Adults (the STRATA Trial).Autism : the international journal of research and practice · 2026Article
- Article
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- Barriers and opportunities for clinical trials in Bahrain: a qualitative study of key opinion leaders.BMJ open · 2026Article
- The Mediation Role of Relatedness and Competence for Patient Activation: A Longitudinal Study of Older Adults with Chronic Illness.Healthcare (Basel, Switzerland) · 2026Article
- Development and Preliminary Validation of a Tool to Assess Barriers and Facilitators to Participation in Adjuvant Endocrine Therapy Switch Trials.Current oncology (Toronto, Ont.) · 2026Article
- Cultural adaptation of Educate, Nurture, Advise, Before Life Ends (ENABLE) for patients with heart failure and their caregivers in South-East Asia - a qualitative formative evaluation study.BMC palliative care · 2026Article
- Ensuring inclusion is central to critical care research design.Intensive care medicine · 2026Article
- Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe demand for clinical trial participants is today one of the highest it has ever been and continues to increase. At the same time, subject recruitment continues to be problematic and the major reason for clinical trial premature terminations. The literature on clinical trial recruitment, which spans several decades and includes hundreds of studies, has an abundance of findings that can be synthesized by way of an overview to provide a well-informed and complete picture of the factors that determine subject participation.
objectivesAn overview of the systematic reviews that report barriers and facilitators to clinical trial participation was conducted. The extracted data were synthesized, and a thematic framework of the factors that affect subject participation in clinical trials was developed. The overview extended across medical subjects and demographics.
methodsThirty reviews that complied with the inclusion criteria were included. These reviews covered 753 relevant primary studies and reported 881 barriers and facilitators. The barriers and facilitators were thematically synthesized and a thematic framework of 20 themes was developed. The quality of the included reviews was assessed and reported. MAIN
resultsSeveral opportunities to increase clinical trial participation, by developing interventions and changing the trial design, derived from an analysis of the thematic framework. That analysis also showed that most of the 20 themes operate mainly as a barrier or as a facilitator, and that most have an effect across medical subjects. As to the quality elements assessed, some reviews complied almost fully but most only partially.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.