ArticleContemporary clinical trials communications2021
Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs.
Article in Contemporary clinical trials communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Effectiveness of a Transdiagnostic Emotion-Focused Treatment in Clinical Care: A Sequential Single-Case Experimental Design.European journal of pain (London, England) · 2026Trial
- Meta-analysis of adverse events in clinical studies with antisense oligonucleotide therapies.Molecular therapy. Nucleic acids · 2026Review
- Can Physical Activity, Sleep Parameters, and Sleep-Wake Patterns Predict Outcome of Combined Chronotherapy in Mood Disorder During Routine Clinical Practice? An Exploratory Study.Journal of personalized medicine · 2026Article
- Improving Experimental Designs for Interventions to Reduce Intimate Partner Violence: Protocol for Refinements to Single-Case Experimental Design for a Safety Planning Intervention in Ontario, Canada.JMIR research protocols · 2025Article
- Report on the rare disease consortium Japan inaugural symposium - July 18, 2023, shonan health innovation park, Japan.Journal of neuromuscular diseases · 2025Article
- Leveraging Single-Case Experimental Designs to Promote Personalized Psychological Treatment: Step-by-Step Implementation Protocol with Stakeholder Involvement of an Outpatient Clinic for Personalized Psychotherapy.Administration and policy in mental health · 2024Article
- The Permutation Distancing Test for dependent single-case observational AB-phase design data: A Monte Carlo simulation study.Behavior research methods · 2024Article
- Exploring the contribution of case study research to the evidence base for occupational therapy: a scoping review.Systematic reviews · 2023Article
- Understanding the scalability of personalised monitoring within indoor spaces.NPJ digital medicine · 2023Article
- Personalised and Sustainable IEQ Monitoring: Use of Multi-Modal and Pervasive Technologies.International journal of environmental research and public health · 2023Article
- Exploring human biology with N-of-1 clinical trials.Cambridge prisms. Precision medicine · 2023Article
- StudyU: A Platform for Designing and Conducting Innovative Digital N-of-1 Trials.Journal of medical Internet research · 2022Article
- Accommodating Serial Correlation and Sequential Design Elements in Personalized Studies and Aggregated Personalized Studies.Harvard data science review · 2022Article
- A protocol for longitudinal monitoring of individual building occupants and their environments.PloS one · 2022Article
- Individual Postprandial Glycemic Responses to Diet in n-of-1 Trials: Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR).The Journal of nutrition · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this article we briefly examine the unique features of Single-Case Designs (SCDs) (studies in a single participant), their history and current trends, and real-world clinical applications. The International Collaborative Network for N-of-1 Trials and Single-Case Designs (ICN) is a formal collaborative network for individuals with an interest in SCDs. The ICN was established in 2017 to support the SCD scientific community and provide opportunities for collaboration, a global communication channel, resource sharing and knowledge exchange. In May 2021, there were more than 420 members in 31 countries. A member survey was undertaken in 2019 to identify priorities for the ICN for the following few years. This article outlines the key priorities identified and the ICN's progress to date in these key areas including network activities (developing a communications strategy to increase awareness, collecting/sharing a comprehensive set of resources, guidelines and tips, and incorporating the consumer perspective) and scientific activities (writing position papers and guest editing special journal issues, exploring key stakeholder perspectives about SCDs, and working to streamline ethical approval processes for SCDs). The ICN provides a practical means to engage with this methodology through membership. We encourage clinicians, researchers, industry, and healthcare consumers to learn more about and conduct SCDs, and to join us in our mission of using SCDs to improve health outcomes for individuals and populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.