Evidence map›Paper›PMID 34401532›Full record

ArticleBiochemistry and biophysics reports2021

The effect of serum starvation on tight junctional proteins and barrier formation in Caco-2 cells.

Aisling M Ross, Darragh R Walsh, Rachel M Cahalane, Lynnette Marcar, John J E Mulvihill

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Cytokine-Induced Barrier Dysfunction and Lipid Signaling in a Gut-On-Chip Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Animal product-free formation and cultivation of three-dimensional primary hepatocyte spheroids.Drug metabolism and disposition: the biological fate of chemicals · 2025
    Article
  4. Article
  5. Article
  6. International journal of molecular sciences · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aisling M RossBioscience and Bioengineering Research (BioSciBer), Bernal Institute, University of Limerick, Ireland.
Darragh R WalshBioscience and Bioengineering Research (BioSciBer), Bernal Institute, University of Limerick, Ireland.
Rachel M CahalaneBioscience and Bioengineering Research (BioSciBer), Bernal Institute, University of Limerick, Ireland.
Lynnette MarcarBioscience and Bioengineering Research (BioSciBer), Bernal Institute, University of Limerick, Ireland.
John J E MulvihillBioscience and Bioengineering Research (BioSciBer), Bernal Institute, University of Limerick, Ireland.
University of Limerick · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assessing the ability of pharmaceutics to cross biological barriers and reach the site-of-action requires faithful representation of these barriers

Indexed as

Drug deliveryIn vitro modelOccludinSerum-freeTransendothelial electrical resistance (TEER)Zonula occludens-1 (ZO-1)

Identifiers

PMID34401532
PMCPMC8358646
OpenAlexW3189193227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.