Evidence map›Paper›PMID 34401498›Full record

ArticleLaryngoscope investigative otolaryngology2021

Head & neck melanoma: A 22-year experience of recurrence following sentinel lymph node biopsy.

Kristen A Echanique, Shabnam Ghazizadeh, Andy Moon, Kera Kwan, Peter A Pellionisz, Dennis Rünger, David Elashoff, Maie St John

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kristen A EchaniqueDepartment of Otolaryngology-Head and Neck Surgery University of California Los Angeles Los Angeles, California USA.
Shabnam GhazizadehDepartment of Otolaryngology-Head and Neck Surgery University of California Los Angeles Los Angeles, California USA.ORCID https://orcid.org/0000-0003-4867-6889
Andy MoonDepartment of Otolaryngology-Head and Neck Surgery University of California Los Angeles Los Angeles, California USA.
Kera KwanDepartment of Otolaryngology-Head and Neck Surgery University of California Los Angeles Los Angeles, California USA.
Peter A PellioniszDepartment of Otolaryngology-Head and Neck Surgery University of California Los Angeles Los Angeles, California USA.ORCID https://orcid.org/0000-0002-8577-7497
Dennis RüngerDepartment of Medicine Statistics Core University of California Los Angeles Los Angeles, California USA.
David ElashoffDepartment of Medicine Statistics Core University of California Los Angeles Los Angeles, California USA.
Maie St JohnDepartment of Otolaryngology-Head and Neck Surgery University of California Los Angeles Los Angeles, California USA.ORCID https://orcid.org/0000-0001-7068-9534
University of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCI NIH HHS P30 CA016042
6 · The paper itself

Abstract

objectiveTo examine the clinicopathologic factors that contribute to regional and distant recurrence in intermediate to high risk head and neck melanoma patients after sentinel lymph node biopsy (SLNB).

methodsThis study is a retrospective review from an academic tertiary care center. Patients treated with SLNB for head and neck melanoma from 1997 to 2019 were reviewed and characterized by sentinel lymph node (SLN) status. Clinical variables were examined for the impact on regional and distant recurrence in SLNB-negative patients using univariable and multivariable Cox regression analysis.

resultsOne hundred and fifty four patients were included. Of note, 127 (82.5 %) were men, and the average age was 61.3 years. Median follow-up was 68.6 weeks. Pathologic review of SLNs found 3.9% positive for metastatic melanoma; 96.1% were negative. Regional recurrence was significantly associated with tumor stage and age on multivariate analysis. A total of 4.5% of patients recurred in a previously labeled negative basin. Scalp subsite accounted for 30.5% of primary tumors and was more likely to yield a positive SLN on univariate analysis (

conclusionWe report a number of prognostic trends in head and neck melanoma. SLN positivity was found more often in patients with a primary tumor of the scalp. Regional recurrence was significantly associated with age and tumor stage, whereas distant recurrence was significantly associated with tumor staging and scalp subsite. Scalp subsite was associated with an increased risk for nodal metastasis and distant recurrence. LEVEL OF EVIDENCE: 3.

Indexed as

head and neck cancermelanomasentinel lymph node

Identifiers

PMID34401498
PMCPMC8356881
OpenAlexW3176713670

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.