Evidence map›Paper›PMID 34401496›Full record

ReviewLaryngoscope investigative otolaryngology2021

The genomics and epigenetics of olfactory neuroblastoma: A systematic review.

Raman Preet Kaur, Evgeny Izumchenko, Dukagjin M Blakaj, Nikol Mladkova, Matt Lechner, Thomas L Beaumont, Charalampos S Floudas, Gary L Gallia, Nyall R London

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Laryngoscope investigative otolaryngology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Review
  3. Epigenetic alterations in head and neck cancer: a brief update.Virchows Archiv : an international journal of pathology · 2026
    Review
  4. Molecular Profiling of Olfactory Neuroblastoma Using the AACR Project GENIE Database.Journal of neurological surgery. Part B, Skull base · 2026
    Article
  5. Review
  6. DNA Virus Detection in Olfactory Neuroblastomas Using Targeted Enrichment NGS.Neuropathology : official journal of the Japanese Society of Neuropathology · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
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  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Raman Preet KaurDepartment of Otolaryngology - Head and Neck Surgery Johns Hopkins University Baltimore Maryland USA.
Evgeny IzumchenkoSection of Hematology Oncology, Department of Medicine University of Chicago Medicine Chicago Illinois USA.
Dukagjin M BlakajDepartment of Radiation Oncology The Ohio State University Columbus Ohio USA.
Nikol MladkovaDepartment of Radiation Oncology The Ohio State University Columbus Ohio USA.
Matt LechnerDepartment of Otolaryngology-Head and Neck Surgery Stanford University School of Medicine Palo Alto California USA.
Thomas L BeaumontDepartment of Neurosurgery University of California San Diego San Diego California USA.
Charalampos S FloudasGenitourinary Malignancies Branch, Center for Cancer Research National Cancer Institute Bethesda Maryland USA.
Gary L GalliaDepartment of Otolaryngology - Head and Neck Surgery Johns Hopkins University Baltimore Maryland USA.
Nyall R LondonDepartment of Otolaryngology - Head and Neck Surgery Johns Hopkins University Baltimore Maryland USA.ORCID https://orcid.org/0000-0002-2902-4407
Johns Hopkins University · USThe Ohio State University · USNational Cancer Institute · USStanford University · USUniversity of California San Diego · USUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOlfactory neuroblastoma (ONB) or esthesioneuroblastoma (ENB) is a rare malignancy of the nasal cavity believed to arise from the olfactory epithelium. The goal of this study was to systematically review the genomics, epigenetics, and cytogenetics of ONB and to understand the potential clinical implications of these studies.

methodsA systematic literature review was performed for articles published before May 2020 using Cochrane, Embase, Pubmed, and Scopus databases. Inclusion criteria included genomics, cytogenetics, and epigenetics studies on ONB. Exclusion criteria included studies not in English or systematic reviews. Articles and abstracts were reviewed by two independent reviewers to reduce bias during article selection and synthesis of results. Of the 36 studies included in this review, 24 were research articles and 12 were abstracts.

resultsAlthough recurrent mutations among ONB tumors are uncommon, alterations in

conclusionsThe rare character of ONB has limited the sample size available for cytogenetic, genomic, and epigenetic studies and contributes to the limitations of this systematic review. Comprehensive genomic and epigenomic studies with larger cohorts are warranted to validate the initial reports summarized in this review and to identify potential therapeutic targets for ONB.

Indexed as

cytogeneticsepigeneticsgenomicsolfactory neuroblastomatumorigenesis

Identifiers

PMID34401496
PMCPMC8356883
OpenAlexW3166552599

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.