Evidence map›Paper›PMID 34401403›Full record

ReviewMovement disorders clinical practice2021

Movement Disorders and Liver Disease.

Eoin Mulroy, Francesca Baschieri, Francesca Magrinelli, Anna Latorre, Pietro Cortelli, Kailash P Bhatia

Open access · hybridAbstract readReview
In one paragraph

Review in Movement disorders clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Movement Disorders and the Gut: A Review.Movement disorders clinical practice · 2022
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Eoin MulroyDepartment of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology London United Kingdom.
Francesca BaschieriIRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy.ORCID https://orcid.org/0000-0001-7710-8165
Francesca MagrinelliDepartment of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology London United Kingdom.ORCID https://orcid.org/0000-0003-4706-6245
Anna LatorreDepartment of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology London United Kingdom.ORCID https://orcid.org/0000-0001-7103-5209
Pietro CortelliIRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy.ORCID https://orcid.org/0000-0002-3633-8818
Kailash P BhatiaDepartment of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology London United Kingdom.ORCID https://orcid.org/0000-0001-8185-286X
National Hospital for Neurology and Neurosurgery · GBIstituto delle Scienze Neurologiche di Bologna · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association of movement disorders with structural or functional hepatic disease occurs in three principal scenarios: (1) combined involvement of both organ systems from a single disease entity, (2) nervous system dysfunction resulting from exposure to toxic compounds in the setting of defective hepatic clearance, or (3) hepatic and/or neurological injury secondary to exposure to exogenous drugs or toxins. An important early step in the workup of any patient with combined movement disorders and liver disease is the exclusion of Wilson's disease. Diagnostic delay remains common for this treatable disorder, and this has major implications for patient outcomes. Thereafter, a structured approach integrating variables such as age of onset, tempo of progression, nature and severity of liver involvement, movement disorder phenomenology, exposure to drugs/toxins and laboratory/neuroimaging findings is key to ensuring timely diagnosis and disease-specific therapy. Herein, we provide an overview of disorders which may manifest with a combination of movement disorders and liver disease, structured under the three headings as detailed above. In each section, the most common disorders are discussed, along with important clinical pearls, suggested diagnostic workup, differential diagnoses and where appropriate, treatment considerations.

Indexed as

liver diseasesmovement disorders

Identifiers

PMID34401403
PMCPMC8354085
OpenAlexW3161397033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.