Evidence map›Paper›PMID 34401148›Full record

ArticleClinical & translational immunology2021

Expansion of CD45RA

Yeongbeen Kwon, Kyo Won Lee, You Min Kim, Hyojun Park, Min Kyung Jung, Young Joon Choi, Jin Kyung Son, JuHee Hong, Su-Hyung Park, Ghee Young Kwon and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical & translational immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. CPHEN-016: Comprehensive phenotyping of human regulatory T cells.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yeongbeen KwonSamsung Advanced Institute for Health Sciences & Technology (SAIHST) Graduate School Department of Health Sciences & Technology Sungkyunkwan University Seoul Korea.
Kyo Won LeeTransplantation Research Center Samsung Medical Center Samsung Biomedical Research Institute Seoul Korea.
You Min KimGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Korea.
Hyojun ParkTransplantation Research Center Samsung Medical Center Samsung Biomedical Research Institute Seoul Korea.
Min Kyung JungGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Korea.
Young Joon ChoiGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Korea.
Jin Kyung SonTransplantation Research Center Samsung Medical Center Samsung Biomedical Research Institute Seoul Korea.
JuHee HongTransplantation Research Center Samsung Medical Center Samsung Biomedical Research Institute Seoul Korea.
Su-Hyung ParkGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Korea.
Ghee Young KwonDepartment of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.
Heejin YooStatistics and Data Center Samsung Medical Center Research Institute for Future Medicine Seoul Korea.
Kyunga KimStatistics and Data Center Samsung Medical Center Research Institute for Future Medicine Seoul Korea.
Sung Joo KimTransplantation Research Center Samsung Medical Center Samsung Biomedical Research Institute Seoul Korea.
Jae Berm ParkSamsung Advanced Institute for Health Sciences & Technology (SAIHST) Graduate School Department of Health Sciences & Technology Sungkyunkwan University Seoul Korea.
Eui-Cheol ShinGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Korea.ORCID https://orcid.org/0000-0002-6308-9503

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSimultaneous transplantation of a solid organ and bone marrow from the same donor is a possible means of achieving transplant tolerance. Here, we attempted to identify biomarkers that indicate transplant tolerance for discontinuation of immunosuppressants in combined kidney and bone marrow transplantation (CKBMT).

methodsConventional kidney transplant (KT) recipients (

resultsAmong six CKBMT recipients, three successfully discontinued immunosuppressants (tolerant group) and three could not (non-tolerant group). The CD45RA

conclusionThus, our findings propose a biomarker that can distinguish CKBMT patients who achieve transplant tolerance and are eligible for discontinuation of immunosuppressants and may provide insight into tolerance mechanisms in CKBMT.

Indexed as

chimerismcombined kidney and bone marrow transplantationregulatory T cellstolerance

Identifiers

PMID34401148
PMCPMC8353318

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.