ReviewFood science & nutrition2021
The relationship between the use of artificial sweeteners and cancer: A meta-analysis of case-control studies.
Review in Food science & nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Investigating the relationship between taste perception of artificial sweeteners and cancer risk.Public health nutrition · 2026Article
- Article
- Consumption of non-sugar sweeteners by Brazilian adolescents and adults in 2017-2018: Socioeconomic distribution and food sources.PloS one · 2025Article
- The association of artificial sweeteners intake and risk of cancer: an umbrella meta-analysis.Frontiers in medicine · 2025Review
- Long-term exposure of sucralose induces neuroinflammation and ferroptosis in human microglia cells via SIRT1/NLRP3/IL-1β/GPx4 signaling pathways.Food science & nutrition · 2024Article
- Chronic Use of Artificial Sweeteners: Pros and Cons.Nutrients · 2024Review
- Non-nutritive Sweeteners: Weight Loss or Weight Gain?Endocrine, metabolic & immune disorders drug targets · 2024Review
- Unveiling the profound influence of sucralose on metabolism and its role in shaping obesity trends.Frontiers in nutrition · 2024Review
- The Impact of Artificial Sweeteners on Human Health and Cancer Association: A Comprehensive Clinical Review.Cureus · 2023Review
- Review
- Aspartame Safety as a Food Sweetener and Related Health Hazards.Nutrients · 2023Review
- Article
- Development of a Primary Human Intestinal Epithelium Enriched in L-Cells for Assay of GLP-1 Secretion.Analytical chemistry · 2022Article
- Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.PLoS medicine · 2022Article
- The relationship between the use of artificial sweeteners and cancer: A meta-analysis of case-control studies.Food science & nutrition · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although there are reports that artificial sweeteners (AS) are safe, the relationship between artificial sweeteners and cancer remains controversial. The purpose of the study is to evaluate whether the consumption of artificial sweeteners is associated with the risk of cancers. We conducted a comprehensive search of multiple databases, including MEDLINE, EMBASE, Web of Science, and Cochrane Library. We found all the literature that studied the relationship between artificial sweeteners and cancer. Ten case-control studies were included in the meta-analysis. Our findings indicated that the consumption of artificial sweeteners was not associated with an increase in cancer when all types of cancers are analyzed comprehensively (OR 0.91, 95% CI 0.75-1.11). Interestingly, the use of artificial sweeteners is inversely related to urinary system cancer risk when analyzing women individually (OR 0.76, 95% CI 0.60-0.97). Our meta-analysis found that these is no correlation between artificial sweeteners and occurrence of cancer except urinary system cancer in women. Considering some limitations found in this study, additional data from large clinical trials are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.