Evidence map›Paper›PMID 34401074›Full record

ArticleFood science & nutrition2021

Effect of chronic administration with human thioredoxin-1 transplastomic lettuce on diabetic mice.

Rie Watanabe, Hiroki Ashida, Mikiko Kobayashi-Miura, Akiho Yokota, Junji Yodoi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food science & nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Rie WatanabeLaboratory of Infection and Prevention Department of Biological Responses Institute for Virus Research Kyoto University Kyoto Japan.ORCID https://orcid.org/0000-0003-2205-1821
Hiroki AshidaGraduate School of Biological Sciences Nara Institute of Science and Technology (NAIST) Nara Japan.
Mikiko Kobayashi-MiuraLaboratory of Infection and Prevention Department of Biological Responses Institute for Virus Research Kyoto University Kyoto Japan.
Akiho YokotaGraduate School of Biological Sciences Nara Institute of Science and Technology (NAIST) Nara Japan.
Junji YodoiLaboratory of Infection and Prevention Department of Biological Responses Institute for Virus Research Kyoto University Kyoto Japan.
Kyoto University · JPKobe University · JPNara Institute of Science and Technology · JPShimane University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

scopeHuman thioredoxin-1 (hTrx-1) is a defensive protein induced by various stresses and exerts antioxidative and anti-inflammatory effects. Previously, we described a transplastomic lettuce overexpressing hTrx-1 that exerts a protective effect against oxidative damage in a pancreatic β-cell line. In this study, we treated diabetic mice (Akita mice) with exogenous hTrx-1 and evaluated the effects. METHODS AND

resultsTreatment with drinking water and single applications of exogenous hTrx-1 did not influence the feeding, drinking behavior, body weight, blood glucose, or glycosylated hemoglobin (HbA

conclusionOur results revealed that the administration of an hTrx-1 lettuce-containing diet improves the baseline level of HbA

Indexed as

Akita mouselettucenutritional therapysmall intestinethioredoxin‐1

Identifiers

PMID34401074
PMCPMC8358336
OpenAlexW3177115809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.