ArticleNature neuroscience2021
Placental endocrine function shapes cerebellar development and social behavior.
Open access · hybridAbstract read
In one paragraph
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
32.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- From placenta to the foetus: a systematic review of in vitro models of stress- and inflammation-induced depression in pregnancy.Molecular psychiatry · 2025Pooled it
- Progesterone for Neurodevelopment in Fetuses With Congenital Heart Defects: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Associations between chronic placental inflammation, fetal brain development and later autism traits.Brain, behavior, & immunity - health · 2026Article
- Placenta-Derived Extracellular Vesicles (pdEVs): Key Mediators That Affect the Metabolic Health of Offspring in Early Nutritional Environments.Biomolecules · 2026Review
- Review
- Unraveling sexually dimorphic offspring behaviors: maternal premating stress and the neuro-microbial-metabolic network.Molecular psychiatry · 2026Article
- Placental Insulin-like Growth Factor 1 Insufficiency Drives Neurodevelopmental Disorder-Relevant Behavioral Changes with Sex-Specific Vulnerabilities.bioRxiv : the preprint server for biology · 2026Article
- Maternal Milk Allopregnanolone May Buffer Negative Associations Between Maternal Postpartum Psychological Distress and Infant Regulatory Capacity.Developmental psychobiology · 2026Article
- Cerebellar Abnormalities: A Component of Autism Pathophysiology.Medicina (Kaunas, Lithuania) · 2026Review
- Comprehensive Analysis of the Placenta-Cortex Transcriptomic Database Reveals a Neuroactive Ligand-Receptor Dysregulation After Prenatal Alcohol Exposure.International journal of molecular sciences · 2026Article
- Placental vascular abnormality is associated with worse neurodevelopmental outcomes for infants with congenital heart disease and genetic abnormality.Early human development · 2026Article
- Neonatal hyperoxia exposure causes cerebellar lesions and behavioral abnormalities in rats.Scientific reports · 2026Article
- Folic acid ameliorates placental structure and function in fetal growth restriction via epigenetic modifications.Clinical epigenetics · 2025Article
- Placental Igf1 overexpression sex-specifically impacts mouse placenta structure, altering offspring striatal development and behavior.Experimental neurology · 2025Article
- Double-hit of MIA and Nod2 deficiency induces sex-specific offspring behavioral abnormalities through placental dysregulation.Translational psychiatry · 2025Article
- Microglia alter sex-specific cerebellar myelination following placental hormone loss.Nature communications · 2025Article
- Maternal stressors disrupt mouse placental proteome and fetal brain development in a sex-specific fashion through inflammation and oxidative stress.Molecular psychiatry · 2025Article
- A head start: The relationship of placental factors to craniofacial and brain development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Review
- Congenital Heart Diseases and Neurodevelopmental Disorders: New Insights Through the DOHaD Hypothesis.JACC. Basic to translational science · 2025Review
- Neuroactive steroid exposure impacts neurodevelopment: Comparison of human and rodent placental contribution.Journal of neuroendocrinology · 2025Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 4 countries.
Claire-Marie VacherDepartment of Pediatrics, Columbia University, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. cv2494@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-2966-8149
Helene LacailleDepartment of Pediatrics, Columbia University, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.
Jiaqi J O'ReillyDepartment of Pediatrics, Columbia University, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.
Jacquelyn SalzbankDepartment of Pediatrics, Columbia University, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA.
Dana BakalarNational Institutes of Health, Bethesda, MD, USA.
Sonia SebaouiCenter for Neuroscience Research, Children's National Health System, Washington, DC, USA.
Philippe LiereU1195 INSERM, Paris-Saclay University, Le Kremlin-Bicêtre Cedex, France.
Cheryl Clarkson-ParedesThe George Washington University, Nanofabrication and Imaging Center, Washington, DC, USA.
Toru SasakiCenter for Neuroscience Research, Children's National Health System, Washington, DC, USA.
Aaron SathyanesanCenter for Neuroscience Research, Children's National Health System, Washington, DC, USA.
Panagiotis KratimenosCenter for Neuroscience Research, Children's National Health System, Washington, DC, USA.
Jacob EllegoodMouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-1504-3321
Jason P LerchMouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, ON, Canada.
Yuka ImamuraDepartment of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Pittsburgh, PA, USA.
Anastas PopratiloffThe George Washington University, Nanofabrication and Imaging Center, Washington, DC, USA.
Kazue Hashimoto-ToriiCenter for Neuroscience Research, Children's National Health System, Washington, DC, USA.ORCID http://orcid.org/0000-0003-4001-8259
Vittorio GalloCenter for Neuroscience Research, Children's National Health System, Washington, DC, USA.ORCID http://orcid.org/0000-0002-2429-0845
Michael SchumacherU1195 INSERM, Paris-Saclay University, Le Kremlin-Bicêtre Cedex, France.
Anna A PennDepartment of Pediatrics, Columbia University, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. aap2216@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-1539-5220
Children's National · USMorgan Stanley Children's Hospital · USGeorge Washington University · USHospital for Sick Children · CAInserm · FRNational Institutes of Health · USPennsylvania State University · US
Funding
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9MNovel Roles of Placental Allopregnanolone in Brain Development and InjuryR01HD092593 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANNA A PENN · 2017 to 2026
$3.9MMechanisms of Oligodendrocyte and Axonal Abnormalities After Perinatal Brain InjuryR37NS109478 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI GALLO, VITTORIO · 2018 to 2025
$3.1MADVANCED GRADUATE TRAINING PROGRAM IN NEUROBIOLOGY & BEHAVIORT32NS064928 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENGST, ULRICH · 2010 to 2024
$3.0MPlacental Allopregnanolone is Essential for Development of Cortical GABAergic SignalingF31HD098886 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI O'REILLY, JULIA JIAQI · 2019 to 2020
$74kNICHD NIH HHS F31 HD098886NICHD NIH HHS R01 HD092593NICHD NIH HHS U54 HD090257NINDS NIH HHS R37 NS109478NINDS NIH HHS T32 NS064928
Abstract
Compromised placental function or premature loss has been linked to diverse neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a progesterone-derived GABA-A receptor (GABA
Indexed as
Social BehaviorAldehyde ReductaseAnimalsAutism Spectrum DisorderCerebellumEndocrine GlandsFemaleGABA AgonistsGABA ModulatorsGene DeletionHumansInfantInfant, NewbornMaleMiceMuscimolAldehyde Reductasealdo-keto reductase family 1, member C14 protein, mouseGABA AgonistsGABA ModulatorsMuscimolPregnanoloneReceptors, GABA-A
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What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.