Evidence map›Paper›PMID 34400811›Full record

ArticleEuropean journal of human genetics : EJHG2022

Non-invasive prenatal testing (NIPT) and pregnant women's views on good motherhood: a qualitative study.

Elisa Garcia, Lidewij Henneman, Janneke T Gitsels-van der Wal, Linda Martin, Isabel Koopmanschap, Mireille N Bekker, Danielle R M Timmermans

Open access · bronzeAbstract read
In one paragraph

Article in European journal of human genetics : EJHG, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Attitudes About NIPT Routinisation: A Report from a Qualitative Study of 20 UK Healthcare Professionals.Health care analysis : HCA : journal of health philosophy and policy · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Negotiating Awareness: Dutch Midwives' Experiences of Noninvasive Prenatal Screening Counseling.International journal of environmental research and public health · 2022
    Article
  10. NIPT and the concerns regarding 'routinisation'.European journal of human genetics : EJHG · 2022
    Article
  11. What's new in genetics in June 2022?European journal of human genetics : EJHG · 2022
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Elisa GarciaDepartment of Public and Occupational Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. e.garciagonzalez@amsterdamumc.nl.ORCID http://orcid.org/0000-0001-6547-220X
Lidewij HennemanDepartment of Clinical Genetics, Section Community Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3531-0597
Janneke T Gitsels-van der WalDepartment of Midwifery Science, Amsterdam UMC, Vrije Universiteit Amsterdam, AVAG, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Linda MartinDepartment of Midwifery Science, Amsterdam UMC, Vrije Universiteit Amsterdam, AVAG, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Isabel KoopmanschapDepartment of Clinical Genetics, Section Community Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.
Mireille N BekkerDepartment of Obstetrics and Gynecology, Utrecht University Medical Center, Utrecht, The Netherlands.
Danielle R M TimmermansDepartment of Public and Occupational Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Amsterdam University Medical Centers · NLDepartment of Health · ZAUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Women's views on responsible motherhood influence decision-making regarding participation in prenatal screening. Previous studies showed that the probabilistic nature of the first-trimester combined test and the potential requirement for subsequent invasive diagnostics serve as legitimate reasons for women to exclude prenatal screening from their moral responsibilities. These moral barriers might now be less relevant with the introduction of the non-invasive prenatal test (NIPT) resulting in women feeling a moral duty to use NIPT screening as part of responsible motherhood. This qualitative study explores the impact of NIPT on women's moral beliefs about the meaning of prenatal screening in relation to responsible motherhood. We performed semi-structured interviews with 29 pregnant women who were offered NIPT as a first-tier screening test within a Dutch nationwide study (TRIDENT-2). Results show that the inherent uncertainty about the fetus's health despite improved accuracy and the lack of treatment for a detected disorder, combined with the possibility to obtain information about actionable anomalies through the fetal anomaly scan, support women's perspectives that NIPT is not an obligation of responsible motherhood. Acceptance of NIPT is considered to be a free decision related to the information each woman needs to be a good mother for her child and her family. Women's views may change when NIPT has expanded to include treatable or preventable conditions.

Indexed as

Down SyndromeFemaleHumansPregnancyPregnant PeoplePrenatal DiagnosisQualitative Research

Identifiers

PMID34400811
PMCPMC9177610
OpenAlexW3195872354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.