ArticleMolecular psychiatry2021
Organizational principles of amygdalar input-output neuronal circuits.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 44 citations in OpenAlex.
- A basolateral amygdala to dorsolateral striatum projection modulates stimulus-evoked motor behavior.Neuron · 2026Article
- Sex differences in neural circuits driving binge-like drinking: a female-specific role for an amygdalo-striatal pathway.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity.Molecular autism · 2026Article
- Projection-specific roles of basolateral amygdala Thy1 neurons in alcohol-induced place preference.Molecular psychiatry · 2026Article
- Risk reshapes amygdala representation of choice.bioRxiv : the preprint server for biology · 2025Article
- Coding principles and mechanisms of serotonergic transmission modes.Molecular psychiatry · 2025Article
- Coding principles of dopaminergic transmission modes.Science advances · 2025Article
- Brain-wide 3D neuron detection and mapping with deep learning.Neurophotonics · 2025Article
- Treadmill exercise prevents stress-induced anxiety-like behaviors via enhancing the excitatory input from the primary motor cortex to the thalamocortical circuit.Nature communications · 2025Article
- Muscarinic acetylcholine receptor activated effectors in principal neurons of the rat basolateral amygdala.Frontiers in cellular neuroscience · 2025Article
- Neuropeptide Y neurons in the basolateral amygdala project to the nucleus accumbens and stimulate high-fat intake.Frontiers in cellular neuroscience · 2025Article
- Identification of a stress-responsive subregion of the basolateral amygdala in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- AMP-Activated Protein Kinase Treatment Ameliorates Chronic Restraint Stress Induced Memory Impairment in Early Adolescent Rat by Restoring Metabolite Profile and Synaptic Proteins.Neurochemical research · 2024Article
- Association of neuroimaging measures with facial emotional processing in healthy adults: a task fMRI study.Social cognitive and affective neuroscience · 2024Article
- Acute stress activates basolateral amygdala neurons expressing corticotropin-releasing hormone receptor type 1 (CRHR1): Topographical distribution and projection-specific activation in male and female rats.Neurobiology of stress · 2024Article
- Intra-BLA alteration of interneurons' modulation of activity in rats, reveals a dissociation between effects on anxiety symptoms and extinction learning.Neurobiology of stress · 2024Article
- Delineating structural and metabolic abnormalities in amygdala and hippocampal subfields for different seizure-onset patterns via stereotactic electroencephalography.CNS neuroscience & therapeutics · 2024Article
- Synergism between two BLA-to-BNST pathways for appropriate expression of anxiety-like behaviors in male mice.Nature communications · 2024Article
- Basolateral amygdala neuropeptide Y system modulates binge ethanol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- A rabies virus-based toolkit for efficient retrograde labeling and monosynaptic tracing.Neural regeneration research · 2023Article
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
The amygdala, one of the most studied brain structures, integrates brain-wide heterogeneous inputs and governs multidimensional outputs to control diverse behaviors central to survival, yet how amygdalar input-output neuronal circuits are organized remains unclear. Using a simplified cell-type- and projection-specific retrograde transsynaptic tracing technique, we scrutinized brain-wide afferent inputs of four major output neuronal groups in the amygdalar basolateral complex (BLA) that project to the bed nucleus of the stria terminals (BNST), ventral hippocampus (vHPC), medial prefrontal cortex (mPFC) and nucleus accumbens (NAc), respectively. Brain-wide input-output quantitative analysis unveils that BLA efferent neurons receive a diverse array of afferents with varied input weights and predominant contextual representation. Notably, the afferents received by BNST-, vHPC-, mPFC- and NAc-projecting BLA neurons exhibit virtually identical origins and input weights. These results indicate that the organization of amygdalar BLA input-output neuronal circuits follows the input-dependent and output-independent principles, ideal for integrating brain-wide diverse afferent stimuli to control parallel efferent actions. The data provide the objective basis for improving the virtual reality exposure therapy for anxiety disorders and validate the simplified cell-type- and projection-specific retrograde transsynaptic tracing method.
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