ArticleCommunications biology2021
The functional brain favours segregated modular connectivity at old age unless affected by neurodegeneration.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Auditory Speech Processing Efficiency: Functional Connectivity Graph Theory Analysis of Lexical Processing Effort.bioRxiv : the preprint server for biology · 2026Article
- Connectome-based markers predict the sub-types of frontotemporal dementia.Molecular psychiatry · 2026Article
- The structural reserve of brain networks influences outcomes after a stroke.Brain communications · 2026Article
- Association of Bidirectional Network Cores in the Brain with Perceptual Awareness and Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Association of bidirectional network cores in the brain with perceptual awareness and cognition.bioRxiv : the preprint server for biology · 2025Article
- Structure-function relationships across scales: implications for atlases.Frontiers in neuroscience · 2025Article
- Age-related differences in network controllability are mitigated by redundancy in large-scale brain networks.Communications biology · 2024Article
- Brain signaling becomes less integrated and more segregated with age.bioRxiv : the preprint server for biology · 2024Article
- Brain signaling becomes less integrated and more segregated with age.Network neuroscience (Cambridge, Mass.) · 2024Article
- Altered hippocampal connectivity dynamics predicts memory performance in neuropsychiatric lupus: a resting-state fMRI study using cross-recurrence quantification analysis.Lupus science & medicine · 2023Article
- Intestinal microbiota: a new perspective on delaying aging?Frontiers in microbiology · 2023Review
- A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Longitudinal functional brain network reconfiguration in healthy aging.Human brain mapping · 2020Article
- Functional connectome metrics reveal distinct prognostic subtypes in two Phase 3 gantenerumab trials.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
Abstract
Brain's modular connectivity gives this organ resilience and adaptability. The ageing process alters the organised modularity of the brain and these changes are further accentuated by neurodegeneration, leading to disorganisation. To understand this further, we analysed modular variability-heterogeneity of modules-and modular dissociation-detachment from segregated connectivity-in two ageing cohorts and a mixed cohort of neurodegenerative diseases. Our results revealed that the brain follows a universal pattern of high modular variability in metacognitive brain regions: the association cortices. The brain in ageing moves towards a segregated modular structure despite presenting with increased modular heterogeneity-modules in older adults are not only segregated, but their shape and size are more variable than in young adults. In the presence of neurodegeneration, the brain maintains its segregated connectivity globally but not locally, and this is particularly visible in dementia with Lewy bodies and Parkinson's disease dementia; overall, the modular brain shows patterns of differentiated pathology.
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Registered trials
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