Evidence map›Paper›PMID 34400751›Full record

ArticleNPJ digital medicine2021

iCOVID: interpretable deep learning framework for early recovery-time prediction of COVID-19 patients.

Jun Wang, Chen Liu, Jingwen Li, Cheng Yuan, Lichi Zhang, Cheng Jin, Jianwei Xu, Yaqi Wang, Yaofeng Wen, Hongbing Lu and 6 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jun Wang *School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0000-0001-9115-3755
Chen Liu *Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.ORCID http://orcid.org/0000-0001-5149-2496
Jingwen Li *Department of Gastroenterology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.ORCID http://orcid.org/0000-0001-8299-7390
Cheng Yuan *School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Lichi Zhang *School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0000-0003-4396-4566
Cheng JinDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5269-5375
Jianwei XuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0000-0002-9445-4307
Yaqi WangCollege of Media, Communication University of Zhejiang, Hangzhou, China.ORCID http://orcid.org/0000-0002-4627-3392
Yaofeng WenSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Hongbing LuCollege of Computer Science and Technology, Zhejiang University, Hangzhou, China.
Biao LiDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai, China.
Chang ChenDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Xiangdong LiDepartment of Radiology, General Hospital of Southern Theatre Command, PLA, Guangzhou, China. 903870332@qq.com.ORCID http://orcid.org/0000-0002-0277-5817
Dinggang ShenSchool of Biomedical Engineering, ShanghaiTech University, Shanghai, China. Dinggang.Shen@gmail.com.ORCID http://orcid.org/0000-0002-7934-5698
Dahong QianSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. dahong.qian@sjtu.edu.cn.ORCID http://orcid.org/0000-0001-9715-6674
Jian WangDepartment of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. wangjian_811@yahoo.com.ORCID http://orcid.org/0000-0003-1210-0837

Funding

National Natural Science Foundation of China (National Science Foundation of China) 919591260
6 · The paper itself

Abstract

Most prior studies focused on developing models for the severity or mortality prediction of COVID-19 patients. However, effective models for recovery-time prediction are still lacking. Here, we present a deep learning solution named iCOVID that can successfully predict the recovery-time of COVID-19 patients based on predefined treatment schemes and heterogeneous multimodal patient information collected within 48 hours after admission. Meanwhile, an interpretable mechanism termed FSR is integrated into iCOVID to reveal the features greatly affecting the prediction of each patient. Data from a total of 3008 patients were collected from three hospitals in Wuhan, China, for large-scale verification. The experiments demonstrate that iCOVID can achieve a time-dependent concordance index of 74.9% (95% CI: 73.6-76.3%) and an average day error of 4.4 days (95% CI: 4.2-4.6 days). Our study reveals that treatment schemes, age, symptoms, comorbidities, and biomarkers are highly related to recovery-time predictions.

Identifiers

PMID34400751
PMCPMC8367981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.