ArticleScientific reports2021
Exploring rare cellular activity in more than one million cells by a transscale scope.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
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- The crucial role of intercellular calcium wave propagation triggered by influenza A virus in promoting infection.Cell communication and signaling : CCS · 2025Article
- Cell-to-cell signaling in cell populations with large cell size variability.Biophysical journal · 2025Article
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- Mesoscale heterogeneity is a critical determinant for spiral pattern formation in developing social amoeba.Scientific reports · 2025Article
- SSBD: an ecosystem for enhanced sharing and reuse of bioimaging data.Nucleic acids research · 2025Article
- Automated detection of spontaneous calcium signaling events in prohemocytes of themicroPublication biology · 2025Article
- An Omni-Mesoscope for multiscale high-throughput quantitative phase imaging of cellular dynamics and high-content molecular characterization.Science advances · 2024Article
- Machine Learning-Enhanced Estimation of Cellular Protein Levels from Bright-Field Images.Bioengineering (Basel, Switzerland) · 2024Article
- Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples.Nature communications · 2024Article
- Large-scale cranial window for in vivo mouse brain imaging utilizing fluoropolymer nanosheet and light-curable resin.Communications biology · 2024Article
- Article
- Strength in numbers: Unleashing the potential of trans-scale scope AMATERAS for massive cell quantification.Biophysics and physicobiology · 2024Review
- Visualizing Singularity Phenomenon.Biophysics and physicobiology · 2024Article
- Inferring the roles of individuals in collective systems using information-theoretic measures of influence.Biophysics and physicobiology · 2024Review
- Editorial: Singularity Biology and Beyond.Biophysics and physicobiology · 2024Article
- Unraveling T-cell dynamics using fluorescent timer: Insights from the Tocky system.Biophysics and physicobiology · 2024Review
- Chromophore-assisted light inactivation of target proteins for singularity biology.Biophysics and physicobiology · 2024Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many phenomena of biological systems, not a majority, but a minority of cells act on the entire multicellular system causing drastic changes in the system properties. To understand the mechanisms underlying such phenomena, it is essential to observe the spatiotemporal dynamics of a huge population of cells at sub-cellular resolution, which is difficult with conventional tools such as microscopy and flow cytometry. Here, we describe an imaging system named AMATERAS that enables optical imaging with an over-one-centimeter field-of-view and a-few-micrometer spatial resolution. This trans-scale-scope has a simple configuration, composed of a low-power lens for machine vision and a hundred-megapixel image sensor. We demonstrated its high cell-throughput, capable of simultaneously observing more than one million cells. We applied it to dynamic imaging of calcium ions in HeLa cells and cyclic-adenosine-monophosphate in Dictyostelium discoideum, and successfully detected less than 0.01% of rare cells and observed multicellular events induced by these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.