Evidence map›Paper›PMID 34400677›Full record

ArticleScientific reports2021

Toll-like receptor-4 null mutation causes fetal loss and fetal growth restriction associated with impaired maternal immune tolerance in mice.

Hon Y Chan, Lachlan M Moldenhauer, Holly M Groome, John E Schjenken, Sarah A Robertson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hon Y Chan *Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia.
Lachlan M Moldenhauer *Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia.
Holly M GroomeRobinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia.
John E SchjenkenRobinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia.
Sarah A RobertsonRobinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia. sarah.robertson@adelaide.edu.au.
University of Adelaide · AUUniversity of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal immune adaptation to accommodate pregnancy depends on sufficient availability of regulatory T (Treg) cells to enable embryo implantation. Toll-like receptor 4 is implicated as a key upstream driver of a controlled inflammatory response, elicited by signals in male partner seminal fluid, to initiate expansion of the maternal Treg cell pool after mating. Here, we report that mice with null mutation in Tlr4 (Tlr4

Indexed as

AnimalsChemotaxis, LeukocyteCyclooxygenase 2CytokinesFemaleFetal Growth RetardationFetal ResorptionGestational AgeLoss of Function MutationLymph NodesLymphocyte ActivationMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutCyclooxygenase 2CytokinesMicroRNAsPtgs2 protein, mouseTlr4 protein, mouseToll-Like Receptor 4

Identifiers

PMID34400677
PMCPMC8368181
OpenAlexW3193283016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.