Evidence map›Paper›PMID 34400629›Full record

ArticleNature communications2021

Excessive ammonium assimilation by plastidic glutamine synthetase causes ammonium toxicity in Arabidopsis thaliana.

Takushi Hachiya, Jun Inaba, Mayumi Wakazaki, Mayuko Sato, Kiminori Toyooka, Atsuko Miyagi, Maki Kawai-Yamada, Daisuke Sugiura, Tsuyoshi Nakagawa, Takatoshi Kiba and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
33.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it, 194 citations in OpenAlex.

  1. Pooled it
  2. Plasticity of metabolism in plants.The Plant journal : for cell and molecular biology · 2026
    Review
  3. Article
  4. Article
  5. Nitrogen form substitution identifies nitrogen use efficiency management pathways in maize.Physiology and molecular biology of plants : an international journal of functional plant biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Characterization of the Glutamine Synthetase Gene Family in Wheat (International journal of molecular sciences · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Phenotype Assessment and Putative Mechanisms of Ammonium Toxicity to Plants.International journal of molecular sciences · 2025
    Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Takushi HachiyaDepartment of Molecular and Functional Genomics, Interdisciplinary Center for Science Research, Shimane University, Matsue, Japan. takushi.hachiya@life.shimane-u.ac.jp.ORCID 0000-0003-3719-7620
Jun InabaRIKEN Center for Sustainable Resource Science, Yokohama, Kanagawa, Japan.
Mayumi WakazakiRIKEN Center for Sustainable Resource Science, Yokohama, Kanagawa, Japan.
Mayuko SatoRIKEN Center for Sustainable Resource Science, Yokohama, Kanagawa, Japan.ORCID 0000-0002-9876-5612
Kiminori ToyookaRIKEN Center for Sustainable Resource Science, Yokohama, Kanagawa, Japan.ORCID 0000-0002-6414-5191
Atsuko MiyagiGraduate School of Science and Engineering, Saitama University, Saitama, Saitama, Japan.
Maki Kawai-YamadaGraduate School of Science and Engineering, Saitama University, Saitama, Saitama, Japan.
Daisuke SugiuraGraduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.
Tsuyoshi NakagawaDepartment of Molecular and Functional Genomics, Interdisciplinary Center for Science Research, Shimane University, Matsue, Japan.
Takatoshi KibaGraduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.ORCID 0000-0001-8651-0404
Alain GojonBiochimie et Physiologie Moléculaire des Plantes, CNRS/INRA/SupAgro-M/Montpellier University, Montpellier, France.
Hitoshi SakakibaraGraduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan.ORCID 0000-0001-5449-6492
RIKEN Center for Sustainable Resource Science · JPSaitama University · JPShimane University · JPCentre National de la Recherche Scientifique · FRNagoya University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plants use nitrate, ammonium, and organic nitrogen in the soil as nitrogen sources. Since the elevated CO

Indexed as

Amino AcidsAmmonium CompoundsArabidopsisArabidopsis ProteinsGlutamate-Ammonia LigaseNitratesNitrogenPlant ShootsPlastidsAmino AcidsAmmonium CompoundsArabidopsis ProteinsGLN2 protein, ArabidopsisGlutamate-Ammonia Ligaseglutamine synthetase 2NitratesNitrogen

Identifiers

PMID34400629
PMCPMC8367978
OpenAlexW3195987249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.