Evidence map›Paper›PMID 34400540›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2021

IgG

Janev Fehmi, Alexander J Davies, Jon Walters, Timothy Lavin, Ryan Keh, Alexander M Rossor, Tudor Munteanu, Norman Delanty, Rhys Roberts, Dirk Bäumer and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Inter-Laboratory Validation of Nodal/Paranodal Antibody Testing.Journal of the peripheral nervous system : JPNS · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Guillain-Barré syndrome.Nature reviews. Disease primers · 2024
    Article
  14. Review
  15. Proteinuria is a key to suspect autoimmune nodopathies.European journal of neurology · 2024
    Article
  16. Antibody-Mediated Nodo- and Paranodopathies.Journal of clinical medicine · 2024
    Review
  17. Article
  18. Article
  19. Anti-pan-neurofascin nodopathy: cause of fulminant neuropathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Janev FehmiNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0002-2329-5708
Alexander J DaviesNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Jon WaltersDepartment of Neurology, Morriston Hospital, Swansea, UK.
Timothy LavinManchester Centre for Clinical Neuroscience, Salford Royal NHS Foundation Trust, Salford, UK.
Ryan KehManchester Centre for Clinical Neuroscience, Salford Royal NHS Foundation Trust, Salford, UK.
Alexander M RossorMRC Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, London, UK.
Tudor MunteanuDepartment of Neurology, Beaumont Hospital, Dublin, Ireland.
Norman DelantyDepartment of Neurology, Beaumont Hospital, Dublin, Ireland.
Rhys RobertsDepartment of Clinical Neurosciences, Cambridge Institute for Medical Research, Cambridge, UK.
Dirk BäumerDepartment of Clinical Neurosciences, Cambridge Institute for Medical Research, Cambridge, UK.
Graham LennoxDepartment of Neurology, Great Western Hospital, Swindon, UK.
Simon RinaldiNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK simon.rinaldi@nhs.net.ORCID 0000-0003-2039-3457
University of Oxford · GBBeaumont Hospital · IESalford Royal NHS Foundation Trust · GBGreat Western Hospital · GBMorriston Hospital · GBNational Hospital for Neurology and Neurosurgery · GB

Funding

Medical Research Council MR/P008399/1
6 · The paper itself

Abstract

objectivesWe aimed to define the clinical and serological characteristics of pan-neurofascin antibody-positive patients.

methodsWe tested serum from patients with suspected immune-mediated neuropathies for antibodies directed against nodal/paranodal protein antigens using a live cell-based assay and solid-phase platform. The clinical and serological characteristics of antibody-positive and seronegative patients were then compared. Sera positive for pan-neurofascin were also tested against live myelinated human stem cell-derived sensory neurons for antibody binding.

resultsEight patients with IgG

conclusionsIgG

Indexed as

AutoantibodiesAdrenal Cortex HormonesAdultAgedFemaleHumansImmunoglobulin GImmunoglobulins, IntravenousMaleMiddle AgedPeripheral Nervous System DiseasesAdrenal Cortex HormonesAutoantibodiesImmunoglobulin GImmunoglobulins, Intravenousneuroimmunologyneuropathy

Identifiers

PMID34400540
PMCPMC8458075
OpenAlexW3193812926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.