Evidence map›Paper›PMID 34400522›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Virus Infection Induces Keap1 Binding to Cytokine Genes, Which Recruits NF-κB p50 and G9a-GLP and Represses Cytokine Transcription.

Veronica Elizabeth Burns, Tom Klaus Kerppola

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Veronica Elizabeth BurnsDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-7491-8338
Tom Klaus KerppolaDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI kerppola@umich.edu.ORCID 0000-0002-0611-9446
University of Michigan · US

Funding

Visualization of Combinatorial Epigenetic Marks and Complexes in Animals Using FlR01DA030339 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KERPPOLA, TOM KLAUS · 2010 to 2016
$1.7M
NIDA NIH HHS R01 DA030339
6 · The paper itself

Abstract

Proinflammatory cytokine gene transcription must be moderated to avoid the pathological consequences of excess cytokine production. The relationships between virus infection and the mechanisms that moderate cytokine transcription are incompletely understood. We investigated the influence of Keap1 on cytokine gene induction by Sendai virus infection in mouse embryo fibroblasts. Virus infection induced Keap1 binding to the

Indexed as

NF-kappa BVirus DiseasesAnimalsCytokinesKelch-Like ECH-Associated Protein 1MiceNF-E2-Related Factor 2NF-kappa B p50 SubunitCytokinesKeap1 protein, mouseKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2NF-kappa BNF-kappa B p50 Subunit

Identifiers

PMID34400522
PMCPMC8801183
OpenAlexW3195028066

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.