Evidence map›Paper›PMID 34400433›Full record

ArticleBMJ case reports2021

Extensive thrombosis after COVID-19 vaccine: cause or coincidence?

Luís Lourenço Graça, Maria João Amaral, Marco Serôdio, Beatriz Costa

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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  12. Portal vein thrombosis after second Pfizer/BioNTech coronavirus disease 2019 vaccine.Journal of vascular surgery cases and innovative techniques · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Luís Lourenço GraçaCardiothoracic Surgery, Centro Hospitalar e Universitário de Coimbra EPE, Coimbra, Portugal luislourencograca@gmail.com.ORCID http://orcid.org/0000-0003-3077-1618
Maria João AmaralGeneral Surgery, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.ORCID http://orcid.org/0000-0002-7494-3218
Marco SerôdioGeneral Surgery, HBP Unit and Liver transplantation Unit, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.
Beatriz CostaGeneral Surgery, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.
Hospitais da Universidade de Coimbra · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 62-year-old Caucasian female patient presented with abdominal pain, vomiting and fever 1 day after administration of COVID-19 vaccine. Bloodwork revealed anaemia and thrombocytosis. Abdominal CT angiography showed a mural thrombus at the emergence of the coeliac trunk, hepatic and splenic arteries, and extensive thrombosis of the superior and inferior mesenteric veins, splenic and portal veins, and the inferior vena cava, extending to the left common iliac vein. The spleen displayed extensive areas of infarction. Aetiological investigation included assessment of congenital coagulation disorders and acquired causes with no relevant findings. Administration of COVID-19 vaccine was considered a possible cause of the extensive multifocal thrombosis. After reviewing relevant literature, it was considered that other causes of this event should be further investigated. Thrombosis associated with COVID-19 vaccine is rare and an aetiological relationship should only be considered in the appropriate context and after investigation of other, more frequent, causes.

Indexed as

COVID-19ThrombosisCOVID-19 VaccinesFemaleHumansMiddle AgedSARS-CoV-2Vena Cava, InferiorCOVID-19 VaccinesCOVID-19portal veinunwanted effects / adverse reactionsvenous thromboembolism

Identifiers

PMID34400433
PMCPMC8370539
OpenAlexW3195489998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.