Evidence map›Paper›PMID 34399986›Full record

ReviewMolecular aspects of medicine2021

Innate lymphoid cells (ILC) in SARS-CoV-2 infection.

Amrita Kumar, Weiping Cao, Kedan Endrias, Suresh V Kuchipudi, Suresh K Mittal, Suryaprakash Sambhara

Open access · greenAbstract readReview
In one paragraph

Review in Molecular aspects of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  9. SARS-CoV-2 Infection and Lung Regeneration.Clinical microbiology reviews · 2022
    Review
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  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Amrita KumarImmunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Weiping CaoImmunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Kedan EndriasCollege of Arts and Sciences, Georgia State University, Atlanta, GA, USA.
Suresh V KuchipudiDepartment of Veterinary and Biomedical Sciences and the HUCJ Institutes of Life Sciences, Penn State University, University Park, PA, USA.
Suresh K MittalDepartment of Comparative Pathobiology, Purdue Institute for Inflammation, Immunology and Infectious Disease, and Purdue University Center for Cancer Research, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Suryaprakash SambharaImmunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: ssambhara@cdc.gov.
Centers for Disease Control and Prevention · USGeorgia State University · USPennsylvania State University · USPurdue University West Lafayette · US

Funding

Novel delivery platform and antigen design for an effective COVID-19 vaccineR01AI158177 · NIAID · PURDUE UNIVERSITY · PI MITTAL, SURESH K · 2020 to 2025
$3.9M
NIAID NIH HHS R01 AI158177
6 · The paper itself

Abstract

Innate Lymphoid Cells (ILCs) are a class of innate immune cells that form the first line of defense against internal or external abiotic and biotic challenges in the mammalian hosts. As they reside in both the lymphoid and non-lymphoid tissues, they are involved in clearing the pathogens through direct killing or by secretion of cytokines that modulate the adaptive immune responses. There is burgeoning evidence that these cells are important in clearing viral infections; therefore, it is critical to understand their role in the resolution or exacerbation of the disease caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2). In this review, we summarize the recent findings related to ILCs in response to SARS-CoV-2 infections.

Indexed as

Immunity, InnateAnimalsCOVID-19CytokinesHumansLymphocytesSARS-CoV-2CytokinesInnate lymphoid cellsNK cellsSARS CoV-2

Identifiers

PMID34399986
PMCPMC8361007
OpenAlexW3194672320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.