Evidence map›Paper›PMID 34399856›Full record

ArticleBMC nutrition2021

Effect of a dietary and exercise intervention in women with overweight and obesity undergoing fertility treatments: protocol for a randomized controlled trial.

Kindann Fawcett, Audrey Martinez, Meghan Crimmins, Clark Sims, Elisabet Børsheim, Aline Andres

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04273048 (A Dietary and Exercise Intervention in Overweight and Obese Women Undergoing Fertility Treatment), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04273048 naterminatednot on this map

A Dietary and Exercise Intervention in Overweight and Obese Women Undergoing Fertility Treatment

TypeinterventionalSponsorArkansas Children's Hospital Research InstituteRan2020 to 2022Enrolled14ConditionsInfertility, FemaleArmsDiet Intervention - Group 1, Exercise Intervention - Group 1
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kindann FawcettArkansas Children's Nutrition Center, 15 Children's Way, Slot 512-20B, Little Rock, AR, 72202, USA.
Audrey MartinezArkansas Children's Nutrition Center, 15 Children's Way, Slot 512-20B, Little Rock, AR, 72202, USA.
Meghan CrimminsArkansas Children's Nutrition Center, 15 Children's Way, Slot 512-20B, Little Rock, AR, 72202, USA.
Clark SimsArkansas Children's Nutrition Center, 15 Children's Way, Slot 512-20B, Little Rock, AR, 72202, USA.
Elisabet BørsheimArkansas Children's Nutrition Center, 15 Children's Way, Slot 512-20B, Little Rock, AR, 72202, USA.
Aline AndresArkansas Children's Nutrition Center, 15 Children's Way, Slot 512-20B, Little Rock, AR, 72202, USA. andresaline@uams.edu.ORCID http://orcid.org/0000-0003-2611-2193
Arkansas Children's Nutrition Center · USArkansas Children's Hospital · US

Funding

Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6M
Phenotypic and metabolic characteristics in early childhood leading to obesityR01DK107516 · NIDDK · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI ANDRES, ALINE, BORSHEIM, ELISABET · 2016 to 2020
$1.6M
J. NRSA TrainingTL1TR003109 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI SEXTON, KEVIN WAYNE · 2019 to 2023
$1.5M
Agricultural Research Service USDA ARS 6026-51000-010-New-S3NCATS NIH HHS TL1 TR003109NCATS NIH HHS UL1 TR003107NIDDK NIH HHS R01 DK107516NIDDK NIH HHS R01DK107516
6 · The paper itself

Abstract

backgroundDistinct molecular, inflammatory, and metabolic signatures are present in oocytes and follicular fluid derived from women with obesity when compared to those derived from normal weight women, which suggest existing signals that may program future offspring for metabolic diseases. This study aims to assess the feasibility and efficacy of a peri-conception nutrition and exercise intervention on mitigating obesity-associated changes in oocyte gene expression profiles and follicular fluid metabolites.

methodsThis single blinded randomized control trial will include 120 women with a BMI of 25-45 kg/m DISCUSSION: This study will provide novel data and key information on the impact of a dietary and exercise intervention on oocyte gene expression and follicular fluid content. Results will demonstrate the potential of such intervention in mitigating obesity-induced changes in oocyte gene expression and follicular fluid metabolites.

trial registrationClinicalTrials.gov ( NCT04273048 ): submitted November 13, 2019; posted February 17, 2020.

Indexed as

ExerciseFollicular fluidMediterranean dietObesityOocytePeri-conception

Identifiers

PMID34399856
PMCPMC8367391
OpenAlexW3196149187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.