ArticleGenome biology2021
Retrotransposons as pathogenicity factors of the plant pathogenic fungus Botrytis cinerea.
Article in Genome biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 47 citations in OpenAlex.
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- Integrated taxonomy and genomic analysis of Marssonina zanthoxyli, the causal agent of prickly ash leaf defoliation.BMC genomics · 2026Article
- A multiplant transcriptomic atlas reveals conserved and lineage-specific defense architectures in response toProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Comparative Transcriptomics Reveals an Extracellular Worm Argonaute as an Ancestral Regulator of LTR Retrotransposons.Genome biology and evolution · 2026Article
- Cross-kingdom RNA interference promotes arbuscular mycorrhiza development.Nature plants · 2026Article
- Cross-kingdom RNAi: a universal mechanism of inter-organismal communication with many unknowns.Journal of experimental botany · 2026Review
- An Argonaute protein traffics from nematode to mouse and is a vaccine against parasitic nematodes.EMBO reports · 2026Article
- Diversify and conquer: How effector diversity is shaped by host-microbe co-evolution.PLoS pathogens · 2026Article
- Exploring Genetic Diversity and Inter-/Intraspecific Polymorphism inInternational journal of molecular sciences · 2025Article
- Genetic basis of Fusarium ear rot resistance and productivity traits in a heterozygous multi-parent recombinant inbred intercross (RIX) maize population.BMC plant biology · 2025Article
- Fungal Argonaute proteins act in bidirectional cross-kingdom RNA interference during plant infection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Recombination and transposition drive genomic structural variation potentially impacting life history traits in a host-generalist fungal plant pathogen.BMC biology · 2025Article
- High-quality genome assembly and comparative analysis reveal extensive genomic variation inMicrobial genomics · 2025Article
- Comparative Genomics Reveals Sources of Genetic Variability in the Asexual Fungal Plant Pathogen Colletotrichum lupini.Molecular plant pathology · 2024Article
- The Comparative Genomics of Botryosphaeriaceae Suggests Gene Families ofJournal of fungi (Basel, Switzerland) · 2024Article
- Genome Comparisons betweenJournal of fungi (Basel, Switzerland) · 2024Article
- Genomic insights into bamboo witches' broom disease: pathogenicity and phytohormone biosynthesis inFrontiers in microbiology · 2024Article
- Genetic and molecular landscapes of the generalist phytopathogen Botrytis cinerea.Molecular plant pathology · 2024Review
- A fungal RNA-dependent RNA polymerase is a novel player in plant infection and cross-kingdom RNA interference.PLoS pathogens · 2023Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRetrotransposons are genetic elements inducing mutations in all domains of life. Despite their detrimental effect, retrotransposons can become temporarily active during epigenetic reprogramming and cellular stress response, which may accelerate host genome evolution. In fungal pathogens, a positive role has been attributed to retrotransposons when shaping genome architecture and expression of genes encoding pathogenicity factors; thus, retrotransposons are known to influence pathogenicity.
resultsWe uncover a hitherto unknown role of fungal retrotransposons as being pathogenicity factors, themselves. The aggressive fungal plant pathogen, Botrytis cinerea, is known to deliver some long-terminal repeat (LTR) deriving regulatory trans-species small RNAs (BcsRNAs) into plant cells to suppress host gene expression for infection. We find that naturally occurring, less aggressive B. cinerea strains possess considerably lower copy numbers of LTR retrotransposons and had lost retrotransposon BcsRNA production. Using a transgenic proof-of-concept approach, we reconstitute retrotransposon expression in a BcsRNA-lacking B. cinerea strain, which results in enhanced aggressiveness in a retrotransposon and BcsRNA expression-dependent manner. Moreover, retrotransposon expression in B. cinerea leads to suppression of plant defence-related genes during infection.
conclusionsWe propose that retrotransposons are pathogenicity factors that manipulate host plant gene expression by encoding trans-species BcsRNAs. Taken together, the novelty that retrotransposons are pathogenicity factors will have a broad impact on studies of host-microbe interactions and pathology.
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