ArticleThyroid research2021
Recurrence of carcinoma showing thymus-like differentiation (CASTLE) involving the thyroid gland.
Article in Thyroid research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- The Molecular Landscape of CASTLE: A Rare Thymus-like Head and Neck Cancer.International journal of molecular sciences · 2026Article
- Case Report: Definitive radiotherapy for intrathyroidal thymic carcinoma with neuroendocrine differentiation.Frontiers in oncology · 2026Article
- Clinical characteristics and outcomes of patients with intrathyroidal thymic carcinoma (ITC): a retrospective cohort study.Gland surgery · 2025Article
- Thyroid Malignancies With Thymic Differentiation: Outcomes of Rare SETTLE and CASTLE Tumors.Head & neck · 2025Article
- [Intrathyroid thymic carcinoma: report of a case].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
- Coexistence of intrathyroid thymic carcinoma and papillary thyroid carcinoma: a case report and literature review.Frontiers in oncology · 2024Article
- Case report: Thymoid differentiated carcinoma of thyroid: Two cases.Frontiers in surgery · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarcinoma showing thymus-like differentiation (CASTLE) in the thyroid gland is a rare disease with generally a favorable prognosis. Treatment with surgery and adjuvant radiotherapy has been shown to improve local control and long-term survival rates. In this report, we present a case of a recurrent thyroid gland CASTLE and review the literature on the diagnosis and treatment of this disease. CASE PRESENTATION: A 60-year-old woman, who was diagnosed with a CASTLE thyroid tumor in 2015, had a total thyroidectomy and was maintained on thyroid hormone replacement (levothyroxine). After 5 years, the patient had a recurrence, in an advanced stage unsuitable for surgery. As the patient declined to undergo radiotherapy, she was followed up without intervention and is currently stable after 15 months.
conclusionsCASTLE is a rare disease, diagnosed based on postoperative pathology and immunohistochemistry analysis, especially upon CD5 marker. In case of relapse, treatment options include surgery and radiotherapy; however conservative management without intervention is an acceptable alternative in some cases.
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