Evidence map›Paper›PMID 34399624›Full record

ArticlemBio2021

Inactivation of Transcriptional Regulator FabT Influences Colony Phase Variation of Streptococcus pneumoniae.

Jinghui Zhang, Weijie Ye, Kaifeng Wu, Shengnan Xiao, Yuqiang Zheng, Zhaoche Shu, Yibing Yin, Xuemei Zhang

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Emergence of multidrug-resistant ST876 serotype 14Frontiers in cellular and infection microbiology · 2026
    Article
  4. Article
  5. Competence Regulation inCurrent medicinal chemistry · 2025
    Review
  6. Article
  7. Article
  8. Microbiology spectrum · 2024
    Article
  9. Article
  10. Acyl-AcpB, a FabT corepressor inJournal of bacteriology · 2023
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Jinghui ZhangKey Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Department of Laboratory Medicine, Chongqing Medical Universitygrid.203458.8, Chongqing, People's Republic of China.
Weijie YeDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Kaifeng WuKey Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Department of Laboratory Medicine, Chongqing Medical Universitygrid.203458.8, Chongqing, People's Republic of China.
Shengnan XiaoDepartment of Medicine Laboratory, Children's Hospital of Chongqing Medical Universitygrid.203458.8 Chongqing, People's Republic of China.
Yuqiang ZhengDepartment of Medicine Laboratory, Children's Hospital of Chongqing Medical Universitygrid.203458.8 Chongqing, People's Republic of China.
Zhaoche ShuDepartment of Blood Transfusion, The First Affiliated Hospital of Chongqing Medical Universitygrid.203458.8, Chongqing, People's Republic of China.
Yibing YinKey Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Department of Laboratory Medicine, Chongqing Medical Universitygrid.203458.8, Chongqing, People's Republic of China.
Xuemei ZhangKey Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Department of Laboratory Medicine, Chongqing Medical Universitygrid.203458.8, Chongqing, People's Republic of China.
Chongqing Medical University · CNChildren's Hospital of Chongqing Medical University · CNCentral South University · CNFirst Affiliated Hospital of Chongqing Medical University · CNFirst People’s Hospital of Zunyi · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Streptococcus pneumoniae is an opportunistic pathogen that can alter its cell surface phenotype in response to the host environment. We demonstrated that the transcriptional regulator FabT is an indirect regulator of capsular polysaccharide, an important virulence factor of Streptococcus pneumoniae. Transcriptome analysis between the wild-type D39s and D39Δ

Indexed as

Gene Expression ProfilingGene Expression Regulation, BacterialGene SilencingA549 CellsAllelesAnimalsBacterial ProteinsHumansMiceMutationPhase VariationPhenotypeStreptococcus pneumoniaeTranscription FactorsBacterial ProteinsTranscription Factorscapsular polysaccharideFabTphase variationSpnD39IIIStreptococcus pneumoniae

Identifiers

PMID34399624
PMCPMC8406281
OpenAlexW3195348398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.