ArticlemBio2021
A Fungal Secretome Adapted for Stress Enabled a Radical Wood Decay Mechanism.
Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- What we (still don't) know about wood-degrading fungi: an overview of threats and utilization potentials.Applied microbiology and biotechnology · 2026Review
- Oxidative stress impacts carbon metabolism and induces upregulation of redox enzymes andsmall secreted proteins in the wood-decay fungus.Fungal biology and biotechnology · 2026Article
- Contrasting diversity patterns of brown: and white-rot wood saprotrophs in response to climate and dispersal vectors.FEMS microbiology ecology · 2025Article
- Unlocking the distinctive enzymatic functions of the early plant biomass deconstructive genes in a brown rot fungus by cell-free protein expression.Applied and environmental microbiology · 2024Article
- Methionine oxidation of carbohydrate-active enzymes during white-rot wood decay.Applied and environmental microbiology · 2024Article
- Oxidative stress and culture atmosphere effects on bioactive compounds and laccase activity in the white rot fungusCurrent research in microbial sciences · 2024Article
- Unraveling the roles of coastal bacterial consortia in degradation of various lignocellulosic substrates.mSystems · 2023Article
- Exoproteomic Study and Transcriptional Responses of Laccase and Ligninolytic Peroxidase Genes of White-Rot FungusInternational journal of molecular sciences · 2023Article
- Metabolomics Highlights Different Life History Strategies of White and Brown Rot Wood-Degrading Fungi.mSphere · 2022Article
- A roadmap to understanding diversity and function of coral reef-associated fungi.FEMS microbiology reviews · 2022Article
- Catalases in the pathogenesis ofPeerJ · 2022Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brown rot fungi release massive amounts of carbon from forest deadwood, particularly at high latitudes. These fungi degrade wood by generating small reactive oxygen species (ROS) to loosen lignocellulose, to then selectively remove carbohydrates. The ROS mechanism has long been considered the key adaptation defining brown rot wood decomposition, but recently, we found preliminary evidence that fungal glycoside hydrolases (GHs) implicated in early cell wall loosening might have been adapted to tolerate ROS stress and to synergize with ROS to loosen woody lignocellulose. In the current study, we found more specifically that side chain hemicellulases that help in the early deconstruction of the lignocellulosic complex are significantly more tolerant of ROS in the brown rot fungus Rhodonia placenta than in a white rot fungus (Trametes versicolor) and a soft rot fungus (Trichoderma reesei). Using proteomics to understand the extent of tolerance, we found that significant oxidation of secreted R. placenta proteins exposed to ROS was less than half of the oxidation observed for T. versicolor or T. reesei. The principal oxidative modifications observed in all cases were monooxidation and dioxidation/trioxidation (mainly in methionine and tryptophan residues), some of which were critical for enzyme activity. At the peptide level, we found that GHs in
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Registered trials
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