ArticlemBio2021
Hidden Viral Sequences in Public Sequencing Data and Warning for Future Emerging Diseases.
Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Persistent viral infection in the Drosophila fat body is associated with immune activation at the single cell level.BMC genomics · 2026Article
- Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High-Throughput Sequencing Data Mining.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Molecular characterization of ten viral pathogens causing calf diarrhea in Hanwoo (Bos Taurus coreanae) by next generation sequencing.BMC veterinary research · 2025Article
- Hidden challenges in evaluating spillover risk of zoonotic viruses using machine learning models.Communications medicine · 2025Article
- Exploring the potential of tick transcriptomes for virus screening: A data reuse approach for tick-borne virus surveillance.PLoS neglected tropical diseases · 2025Article
- Development of Dembo-PCR for cattle in accordance with Japanese livestock quarantine guidelines.The Journal of veterinary medical science · 2025Article
- Ancient evolutionary origins of hepatitis E virus in rodents.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Identification of a novel ephemerovirus in a water buffalo (Bubalus bubalis [Linnaeus, 1758]).The Journal of veterinary medical science · 2024Article
- Isolation and genetic characterization of novel bovine parechoviruses from Japanese black cattle.Archives of virology · 2024Article
- Metagenomic analysis reveals high diversity of gut viromes in yaks (Bos grunniens) from the Qinghai-Tibet Plateau.Communications biology · 2024Article
- Highly diverse RNA viruses and phage sequences concealed within birds.Microbiology spectrum · 2024Article
- The astrovirus N-terminal nonstructural protein anchors replication complexes to the perinuclear ER membranes.PLoS pathogens · 2024Article
- Metavirome analysis of domestic sheep in Shaanxi, Gansu, and Ningxia, China.Frontiers in veterinary science · 2024Article
- Divergent Genotype of Hepatitis A Virus in Alpacas, Bolivia, 2019.Emerging infectious diseases · 2023Article
- Metagenomic analysis of herbivorous mammalian viral communities in the Northwest Plateau.BMC genomics · 2023Article
- Benchmarking State-of-the-Art Approaches for Norovirus Genome Assembly in Metagenome Sample.Biology · 2023Article
- Attenuation hotspots in neurotropic human astroviruses.PLoS biology · 2023Article
- Current trends in RNA virus detection through metatranscriptome sequencing data.FEBS open bio · 2023Review
- Discovery of novel papillomaviruses in the critically endangered Malayan and Chinese pangolins.Biology letters · 2023Article
- The First Identification of a Narnavirus in Bigyra, a Marine Protist.Microbes and environments · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA viruses cause numerous emerging diseases, mostly due to transmission from mammalian and avian reservoirs. Large-scale surveillance of RNA viral infections in these animals is a fundamental step for controlling viral infectious diseases. Metagenomic analysis is a powerful method for virus identification with low bias and has contributed substantially to the discovery of novel viruses. Deep-sequencing data have been collected from diverse animals and accumulated in public databases, which can be valuable resources for identifying unknown viral sequences. Here, we screened for infections of 33 RNA viral families in publicly available mammalian and avian sequencing data and found approximately 900 hidden viral infections. We also discovered six nearly complete viral genomes in livestock, wild, and experimental animals: hepatovirus in a goat, hepeviruses in blind mole-rats and a galago, astrovirus in macaque monkeys, parechovirus in a cow, and pegivirus in tree shrews. Some of these viruses were phylogenetically close to human-pathogenic viruses, suggesting the potential risk of causing disease in humans upon infection. Furthermore, infections of five novel viruses were identified in several different individuals, indicating that their infections may have already spread in the natural host population. Our findings demonstrate the reusability of public sequencing data for surveying viral infections and identifying novel viral sequences, presenting a warning about a new threat of viral infectious disease to public health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.