Evidence map›Paper›PMID 34399595›Full record

ArticleInternational journal of immunopathology and pharmacology

Cytokines in various molecular subtypes of breast cancer.

Alexsander Autenshlyus, Kristina Davletova, Nikolay Varaksin, Igor Marinkin, Vyacheslav Lyakhovich

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Expression Profile ofInternational journal of molecular sciences · 2025
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  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Alexsander AutenshlyusFederal Publicly Funded Institution of Higher Education, 217969Novosibirsk State Medical University, Novosibirsk, Russian Federation.
Kristina DavletovaFederal Publicly Funded Institution of Higher Education, 217969Novosibirsk State Medical University, Novosibirsk, Russian Federation.ORCID https://orcid.org/0000-0002-7143-6173
Nikolay Varaksin474593AO Vector-Best, Koltsovo, Novosibirsk Oblast, Russian Federation.
Igor MarinkinFederal Publicly Funded Institution of Higher Education, 217969Novosibirsk State Medical University, Novosibirsk, Russian Federation.
Vyacheslav LyakhovichFederal Publicly Funded Scientific Institution Federal Research Center of Fundamental and Translational Medicine, 113295Institute of Molecular Biology and Biophysics, Novosibirsk, Russian Federation.
Novosibirsk State Medical University · RUFederal Research Center of Fundamental and Translational Medicine · RUState Research Center of Virology and Biotechnology VECTOR · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBreast cancer is a heterogeneous disease that has multiple molecular and morphological subtypes. Nonetheless, the relation between various molecular subtypes and functional characteristics of a tumor in terms of cytokine secretion remains unknown.

methodsWe studied spontaneous and mitogen-induced cytokine secretion by invasive breast carcinoma of no special type (IBC NST; cultured tumors and cultured peripheral blood cells), depending on a molecular tumor subtype (where "mitogens" means "polyclonal activators" (PA): phytohemagglutinin

resultsThe luminal B HER2-positive molecular subtype of IBC NST was found to feature the highest spontaneous secretion of IL-6 and IL-8 and the highest mitogen-induced secretion of IL-6, IL-8, IL-1Ra, and TNF-α by tumors; the highest mitogen-induced secretion of IL-2, IL-6, IL-8, IL-1β, TNF-α, IFN-γ, and G-CSF by peripheral blood cells; and the highest cytokine-producing potential (the ratio of mitogen-induced to spontaneous secretion) of peripheral blood cells for the secretion of IL-6, IL-8, and IL-1Ra as compared to other molecular subtypes. The triple-negative subtype of IBC NST was characterized by the lowest cytokine-producing potential of tumors for the secretion of IL-6 and IL-8 as compared to other molecular subtypes as well as a lower "stimulation index of polyclonal activators" (calculated as (cytokine secretion after incubation with PA)/(spontaneous cytokine secretion)) for IL-18 secretion as compared to luminal subtypes. The XYZ correlated with a suppressive effect of PA on cytokine secretion by tumors of the triple-negative molecular subtype.

conclusionTherefore, our findings indicate that in IBC NST of luminal B HER2-positive and triple-negative molecular subtypes, the cytokine network has distinctive functional features.

Indexed as

Cell LineCell Line, TumorCytokinesFemaleHumansTriple Negative Breast NeoplasmsCytokinescytokinesinvasive carcinoma of no special typemitogensmolecular subtypes

Identifiers

PMID34399595
PMCPMC8375341
OpenAlexW3195387998

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.