ArticleThe Lancet. Oncology2021
Effect of removing race from glomerular filtration rate-estimating equations on anticancer drug dosing and eligibility: a retrospective analysis of National Cancer Institute phase 1 clinical trial participants.
Article in The Lancet. Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Association of uric acid-to-albumin ratio with diabetic kidney disease: A cross-sectional study.Medicine · 2026Article
- Low hemoglobin-albumin-lymphocyte-platelet score as a risk marker for stroke-associated pneumonia in acute ischemic stroke: a retrospective cohort study.Frontiers in neurology · 2026Article
- Elevated platelet-to-lymphocyte ratio is associated with stroke-associated pneumonia in acute ischemic stroke: a retrospective cohort study.Frontiers in neurology · 2026Article
- Total kidney volume as a predictor of measured glomerular filtration rate in patients with solid tumors: a prospective cross-sectional analysis.Journal of nephrology · 2025Article
- Update on the Assessment of GFR in Patients with Cancer.Kidney360 · 2025Review
- Article
- Surgical Outcomes and Sociodemographic Disparities Across All Races: An ACS-NSQIP and NHIS Multi-Institutional Analysis of Over 7.5 Million Patients.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- International Migration and Cardiovascular Health: Unraveling the Disease Burden Among Migrants to North America and Europe.Journal of the American Heart Association · 2024Review
- Impact of the 2021 CKD-EPI equation on anticancer pharmacotherapy in black and non-black cancer patients.Cancer letters · 2024Article
- Impact of race-based calculations of eGFR on the management of muscle invasive bladder cancer.American journal of clinical and experimental urology · 2024Article
- Performance of the race-free CKD-EPI creatinine-based eGFR equation in a Danish cohort with measured GFR.Clinical kidney journal · 2023Article
- Implications of a Race Term in GFR Estimates Used to Predict AKI After Coronary Intervention.JACC. Cardiovascular interventions · 2023Article
- Review
- Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study.BMJ (Clinical research ed.) · 2023Article
- Intravoxel incoherent motion diffusion-weighted MRI of renal parenchyma and its clinical significance in patients with untreated acute leukemia: a pilot study.Abdominal radiology (New York) · 2023Article
- 2009 CKD-EPI glomerular filtration rate estimation in Black individuals outside the United States: a systematic review and meta-analysis.Clinical kidney journal · 2023Article
- Coagulation Function and Type 2 Diabetic Kidney Disease: A Real-World Observational Study.Journal of diabetes research · 2023Observational
- Association between serum complements and kidney function in patients with diabetic kidney disease.Frontiers in endocrinology · 2023Article
- Removing race and body surface area indexation for estimated kidney function based drug dosing: Aminoglycosides as justification of these principles.Pharmacotherapy · 2023Article
- Carboplatin dose calculations for patients with lung cancer: significant dose differences found depending on dosing equation choice.BMC cancer · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundKidney function assessment by estimated glomerular filtration rate (eGFR) equations, such as the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation, is important to determine dosing and eligibility for anticancer drugs. Inclusion of race in eGFR equations calculates a higher eGFR at a given serum creatinine concentration for Black patients versus non-Black patients. We aimed to characterise the effect of removing race from the CKD-EPI equation on dosing and eligibility of anticancer drugs with kidney function cutoffs.
methodsWe did a retrospective analysis of patients enrolled in phase 1 studies sponsored by the Cancer Therapy Evaluation Program between January, 1995, and October, 2010. eGFR based on creatinine (eGFR
findingsDemographics and laboratory values from 340 Black patients (172 men and 168 women) were used. Median age was 57 years (IQR 47-64), median bodyweight was 78·1 kg (67·0-89·8), median body surface area was 1·91 m
interpretationRemoving race from the CKD-EPI equation will calculate a lower eGFR for Black patients and exclude more patients from receiving anticancer therapy, which could lead to undertreatment of Black patients with cancer and adversely affect their outcomes.
fundingNational Institutes of Health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.