Evidence map›Paper›PMID 34399062›Full record

Trial reportAnnals of internal medicine2021

Efficacy of Acupuncture for Chronic Prostatitis/Chronic Pelvic Pain Syndrome : A Randomized Trial.

Yuanjie Sun, Yan Liu, Baoyan Liu, Kehua Zhou, Zenghui Yue, Wei Zhang, Wenbin Fu, Jun Yang, Ning Li, Liyun He and 17 more

3 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Annals of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 68 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 3 pooled it
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03213938 nacompletednot on this map

Acupuncture for Chronic Prostatitis/Chronic Pelvic Pain Syndrome: a Multicenter Randomized Controlled Trial

TypeinterventionalSponsorGuang'anmen Hospital of China Academy of Chinese Medical SciencesRan2017 to 2019Enrolled440ConditionsChronic Prostatitis With Chronic Pelvic Pain SyndromeArmsAcupuncture, Sham acupuncture
NCT05279963 narecruitingnot on this mapstarted 2022, after this paper: background citation

Electroacupuncture for Bladder Pain Syndrome: An Randomized Controlled Trial and Study for Central Mechanism

TypeinterventionalSponsorThe Third Affiliated hospital of Zhejiang Chinese Medical UniversityRan2022 to 2025Enrolled84ConditionsBladder Pain SyndromeArmselectroacupuncture, Amitriptyline, sham electroacupuncture
NCT05890508 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Electro-acupuncture for Long Covid Neuropsychiatric Symptoms: a Prospective, Randomized Sham-controlled, Double-blinded Clinical Trial

TypeinterventionalSponsorHong Kong Baptist UniversityRan2024 to 2026Enrolled150ConditionsLong Covid19, Neuropsychiatric Symptoms, Electro-acupunctureArmsAcupuncture, Sham-acupuncture
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.

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  12. Cheek acupuncture therapy combined with Chinese herbal medicine for female chronic pelvic pain: a retrospective study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 14 institutions in 2 countries.

Yuanjie SunGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Y.S., B.L., Z.Q., J.Z., J.W., X.L., W.W., R.P., H.C., X.W., Z.L.).
Yan LiuKey Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China (Y.L.).ORCID 0000-0002-6433-0151
Baoyan LiuGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Y.S., B.L., Z.Q., J.Z., J.W., X.L., W.W., R.P., H.C., X.W., Z.L.).
Kehua ZhouThedaCare Regional Medical Center - Appleton, Appleton, Wisconsin (K.Z.).
Zenghui YueHengyang Hospital Affiliated to Hunan University of Chinese Medicine, Hengyang, China (Z.Y.).
Wei ZhangThe First Hospital of Hunan University of Chinese Medicine, Changsha, China (W.Z.).
Wenbin FuGuangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China (W.F.).
Jun YangThe First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China (J.Y.).
Ning LiWest China Hospital of Sichuan University, Chengdu, China (N.L.).
Liyun HeChina Academy of Chinese Medical Sciences, Beijing, China (L.H.).
Zhiwei ZangYantai Hospital of Traditional Chinese Medicine, Yantai, China (Z.Z.).
Tongsheng SuShaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, China (T.S.).
Jianqiao FangThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China (J.F.).
Yulong DingBeijing Fengtai Hospital of Integrated Traditional and Western Medicine, Beijing, China (Y.D.).
Zongshi QinGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Y.S., B.L., Z.Q., J.Z., J.W., X.L., W.W., R.P., H.C., X.W., Z.L.).ORCID 0000-0001-5888-461X
Hujie SongXi'an TCM Brain Disease Hospital, Xi'an, China (H.S.).
Hui HuDongfang Hospital Beijing University of Chinese Medicine, Beijing, China (H.H.).
Hong ZhaoLuohu District Hospital of Traditional Chinese Medicine, Shenzhen, China (H.Z.).
Qian MoGuizhou University of Traditional Chinese Medicine, Guiyang, China (Q.M.).
Jing ZhouGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Y.S., B.L., Z.Q., J.Z., J.W., X.L., W.W., R.P., H.C., X.W., Z.L.).
Jiani WuGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Y.S., B.L., Z.Q., J.Z., J.W., X.L., W.W., R.P., H.C., X.W., Z.L.).ORCID 0000-0001-7940-4179
Xiaoxu LiuGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Y.S., B.L., Z.Q., J.Z., J.W., X.L., W.W., R.P., H.C., X.W., Z.L.).
Weiming WangGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Y.S., B.L., Z.Q., J.Z., J.W., X.L., W.W., R.P., H.C., X.W., Z.L.).
Ran PangGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Y.S., B.L., Z.Q., J.Z., J.W., X.L., W.W., R.P., H.C., X.W., Z.L.).
Huan ChenGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Y.S., B.L., Z.Q., J.Z., J.W., X.L., W.W., R.P., H.C., X.W., Z.L.).
Xinlu WangGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Y.S., B.L., Z.Q., J.Z., J.W., X.L., W.W., R.P., H.C., X.W., Z.L.).
Zhishun LiuGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China (Y.S., B.L., Z.Q., J.Z., J.W., X.L., W.W., R.P., H.C., X.W., Z.L.).
Chinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing University of Chinese Medicine · CNAnhui University of Traditional Chinese Medicine · CNBeijing Fengtai Hospital · CNFirst Affiliated Hospital of Hunan University of Traditional Chinese Medicine · CNGuangdong Provincial Hospital of Traditional Chinese Medicine · CNGuiyang College of Traditional Chinese Medicine · CNHunan University · CNShaanxi Provincial Hospital of Traditional Chinese Medicine · CNShenzhen Luohu People's Hospital · CNSichuan University · CNThedaCare · USThe Third Affiliated Hospital of Zhejiang Chinese Medical University · CNYantaishan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcupuncture has promising effects on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), but high-quality evidence is scarce.

objectiveTo assess the long-term efficacy of acupuncture for CP/CPPS.

designMulticenter, randomized, sham-controlled trial. (ClinicalTrials.gov: NCT03213938).

settingTen tertiary hospitals in China.

participantsMen with moderate to severe CP/CPPS, regardless of prior exposure to acupuncture.

interventionTwenty sessions of acupuncture or sham acupuncture over 8 weeks, with 24-week follow-up after treatment. MEASUREMENTS: The primary outcome was the proportion of responders, defined as participants who achieved a clinically important reduction of at least 6 points from baseline on the National Institutes of Health Chronic Prostatitis Symptom Index at weeks 8 and 32. Ascertainment of sustained efficacy required the between-group difference to be statistically significant at both time points.

resultsA total of 440 men (220 in each group) were recruited. At week 8, the proportions of responders were 60.6% (95% CI, 53.7% to 67.1%) in the acupuncture group and 36.8% (CI, 30.4% to 43.7%) in the sham acupuncture group (adjusted difference, 21.6 percentage points [CI, 12.8 to 30.4 percentage points]; adjusted odds ratio, 2.6 [CI, 1.8 to 4.0]; LIMITATION: Sham acupuncture might have had certain physiologic effects.

conclusionCompared with sham therapy, 20 sessions of acupuncture over 8 weeks resulted in greater improvement in symptoms of moderate to severe CP/CPPS, with durable effects 24 weeks after treatment. PRIMARY FUNDING SOURCE: China Academy of Chinese Medical Sciences and the National Administration of Traditional Chinese Medicine.

Indexed as

Acupuncture TherapyAdultChronic DiseaseHumansMalePain MeasurementPelvic PainProstatitis

Identifiers

PMID34399062
OpenAlexW3194061879

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.