ArticleCancer communications (London, England)2021
Global patterns of breast cancer incidence and mortality: A population-based cancer registry data analysis from 2000 to 2020.
Article in Cancer communications (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05732064 (Effects of Low-dose Dexmedetomidine-esketamine Combined Nasal Administration at Night on Perioperative Sleep Quality in Breast Cancer Patients), which is not on this map. Cited by 560 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Low-dose Dexmedetomidine-esketamine Combined Nasal Administration at Night on Perioperative Sleep Quality in Breast Cancer Patients: a Randomized, Double-blind, Placebo-controlled Trial
Who cites it
560 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Association between ERCC5 gene rs17655 polymorphism and the risk of breast cancer: an updated meta-analysis.Environmental health and preventive medicine · 2026Pooled it
- Effect of exercise interventions on cognitive function in breast cancer patients and survivors: a systematic review with meta-analysis.Breast cancer (Tokyo, Japan) · 2025Pooled it
- A systematic review of patient-reported outcome measures (PROMs) to assess health-related quality of life (HRQoL) for breast cancer patients who are undertaking adjuvant endocrine therapy.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Pooled it
- The impact of indocyanine green fluorescence imaging on skin flap necrosis: a systematic review and meta-analysis.BMC surgery · 2025Pooled it
- Digital Behavior Change Interventions to Promote Physical Activity and Reduce Sedentary Behavior Among Survivors of Breast Cancer: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2025Pooled it
- Using Integrative Therapies to Improve Patient-Reported Outcomes in Breast Cancer Survivors: A Living Evidence-Based Clinical Practice Guideline.Journal of evidence-based medicine · 2025Guideline
- Auricular acupressure for insomnia in women with breast cancer: A systematic review and meta-analysis of randomized controlled trials.Medicine · 2025Pooled it
- Exploratory phase II trial of an anti-PD-1 antibody camrelizumab combined with a VEGFR-2 inhibitor apatinib and chemotherapy as a neoadjuvant therapy for triple-negative breast cancer (NeoPanDa03): efficacy, safety and biomarker analysis.Signal transduction and targeted therapy · 2025Trial
- Effects of rhomboid intercostal nerve, serratus anterior plane, and paravertebral block on the quality of recovery after breast cancer surgery: a randomized controlled clinical trial.BMC anesthesiology · 2025Trial
- Understanding breast cancer causes: insights from Jordanian women's awareness.Future science OA · 2026Article
- Breast Cancer-Derived AZU1 Educates Neutrophils to Promote Tumor Progression and Metastasis Through PAD4-Dependent Extracellular Trap Formation.Molecular carcinogenesis · 2026Article
- The Increasing Importance of Breast Cancer in the United Arab Emirates.Asia-Pacific journal of clinical oncology · 2026Review
- Temporal and geographic patterns of breast cancer-related google search activity and its association with CDC-reported incidence in the United States (2005-2023).Annals of medicine and surgery (2012) · 2026Article
- Development and validation of a SEER-derived prognostic nomogram for non-metastatic Asian breast cancer patients.Gland surgery · 2026Article
- Pembrolizumab plus chemotherapy followed by pembrolizumab in participants in Asia with early triple-negative breast cancer: An updated subgroup analysis of the KEYNOTE-522 randomized clinical trial.Breast (Edinburgh, Scotland) · 2026Article
- Impact of neoadjuvant chemotherapy on breast tissue density and its correlation with pathologic response: a retrospective artificial intelligence-enhanced radiological study.The British journal of radiology · 2026Article
- From pixels to pathology: how artificial intelligence mammographic risk scores capture tumor biology through imaging.European radiology · 2026Article
- Determinants of Early-Stage Breast Cancer Presentation in Western Kazakhstan: A Population-Based Analysis of Urban-Rural Disparities and Diagnostic Pathways (2015-2025).Medicina (Kaunas, Lithuania) · 2026Article
- Astaxanthin attenuates CTX-induced premature ovarian failure by alleviating ovarian apoptosis and autophagy in vivo.Journal of ovarian research · 2026Article
- Intrasystem Repeatability of S-Detect for Breast Ultrasound Classification With Identical Static Images: Single-Center Retrospective Repeatability Study.JMIR medical informatics · 2026Article
500 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
backgroundBreast cancer is the most commonly diagnosed cancer and leading cause of cancer death among women worldwide but has patterns and trends which vary in different countries. This study aimed to evaluate the global patterns of breast cancer incidence and mortality and analyze its temporal trends for breast cancer prevention and control.
methodsBreast cancer incidence and mortality data in 2020 were obtained from the GLOBOCAN online database. Continued data from the Cancer Incidence in Five Continents Time Trends, the International Agency for Research on cancer mortality and China National Central Cancer Registry were used to analyze the time trends from 2000 to 2015 through Joinpoint regression, and annual average percent changes of breast cancer incidence and mortality were calculated. Association between Human Development Index and breast cancer incidence and mortality were estimated by linear regression.
resultsThere were approximately 2.3 million new breast cancer cases and 685,000 breast cancer deaths worldwide in 2020. Its incidence and mortality varied among countries, with the age-standardized incidence ranging from the highest of 112.3 per 100,000 population in Belgium to the lowest of 35.8 per 100,000 population in Iran, and the age-standardized mortality from the highest of 41.0 per 100,000 population in Fiji to the lowest of 6.4 per 100,000 population in South Korea. The peak age of breast cancer in some Asian and African countries were over 10 years earlier than in European or American countries. As for the trends of breast cancer, the age-standardized incidence rates significantly increased in China and South Korea but decreased in the United States of America (USA) during 2000-2012. Meanwhile, the age-standardized mortality rates significantly increased in China and South Korea but decreased in the United Kingdom, the USA, and Australia during 2000 and 2015.
conclusionsThe global burden of breast cancer is rising fast and varies greatly among countries. The incidence and mortality rates of breast cancer increased rapidly in China and South Korea but decreased in the USA. Increased health awareness, effective prevention strategies, and improved access to medical treatment are extremely important to curb the snowballing breast cancer burden, especially in the most affected countries.
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