ArticlePloS one2021
The influence of childhood adversities on mid to late cognitive function: From the perspective of life course.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive impairment and dementia-Are they linked to childhood health and socioeconomic status? A systematic review.PloS one · 2025Pooled it
- Association of Adverse Childhood Experiences and Cognitive Health in Older Adults: Rush Memory and Aging Project.The American journal of geriatric psychiatry. Open science, education, and practice · 2026Article
- Associations of childhood economic and psychosocial conditions with later-life cognitive function: a longitudinal analysis of the China health and retirement longitudinal study (2011-2020).BMC public health · 2026Article
- Exposure to parental depression in childhood and memory trajectories in mid- and later life.PloS one · 2026Article
- Adverse experiences in childhood and young adulthood, genetic susceptibility, and neurodegenerative disease incidence: a lifespan analysis.European journal of psychotraumatology · 2025Article
- The mediating role of life course cognitive reserve-enhancing factors in the relationship between adverse childhood experiences and dementia among older adults: evidence from a prospective cohort study in the United States.Social psychiatry and psychiatric epidemiology · 2025Article
- Late-Life Informal Social Participation, Physical and Cognitive Functions Among the Chinese Elderly: A Life Course Perspective.Healthcare (Basel, Switzerland) · 2025Article
- Sex Differences in the Associations Among Early Life Adversity, Inflammation, and Cognition.Biomolecules · 2025Review
- Cognitive enrichment improves spatial memory and alters hippocampal synaptic connectivity in a mouse model for early-life stress.Frontiers in cellular neuroscience · 2025Article
- The impact of early adversity on later life health, lifestyle, and cognition.BMC public health · 2024Article
- Childhood adversities and memory function in later life: the mediating role of activity participation.BMC geriatrics · 2024Article
- Article
- No Association Found: Adverse Childhood Experiences and Cognitive Impairment in Older Australian Adults.The journal of prevention of Alzheimer's disease · 2024Article
- Distinct domains of childhood disadvantage and cognitive performance among older Brazilians: Evidence from ELSI-Brazil.SSM - population health · 2023Article
- Early life adversity as a risk factor for cognitive impairment and Alzheimer's disease.Translational neurodegeneration · 2023Review
- Area level indirect exposure to extended conflicts and early childhood anthropometric outcomes in India: a repeat cross-sectional analysis.Conflict and health · 2023Article
- Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity.Theranostics · 2023Article
- Cognition and Cognitive Changes in a Low-Income Sub-Saharan African Aging Population.Journal of Alzheimer's disease : JAD · 2023Article
- Association of Adverse Childhood Experiences and Social Isolation With Later-Life Cognitive Function Among Adults in China.JAMA network open · 2022Article
- A Scoping Review on Biopsychosocial Predictors of Mental Health among Older Adults.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effects of childhood adversities on cognitive function in later life are well reported. However, few studies have examined the cumulative mechanism, especially in Chinese population. This study aims to explore this cumulative effects of childhood adversities on mid to late cognitive decline in China.
methodsData were drawn from the second and third wave of the China Health and Retirement Longitudinal Study (CHARLS). We included 9,942 respondents aged 45 and above and retrospectively collected information on childhood adversities. Cognitive function was measured in three dimensions: orientation and calculation, immediate memory, and delayed memory. A structural equation model was employed for analysis.
resultsAge (β = -0.155, P<0.001) and mid to late depressive symptoms (β = -0.041, P<0.001) showed direct effects on cognitive decline. Low mid to late life socioeconomic status (SES) showed a direct effect on mid-late cognitive impairment (β = 0.603, P<0.001) and an indirect effect through depression (β = 0.007, P<0.001). Low childhood SES (β = 0.310, P<0.001), lack of friends (β = 0.208, P<0.001), parental mental health problems (β = 0.008, P<0.001), and poor relationship with parents (β = 0.001, P<0.001) had an indirect effect on cognitive impairment.
conclusionsChildhood adversities had negative effects on cognitive function among middle aged and elderly population in China. The findings suggest that early counter measures on childhood adversities may lead to an effective reduction of cognitive impairment.
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