Evidence map›Paper›PMID 34398668›Full record

ArticleAntimicrobial agents and chemotherapy2021

Exebacase in Addition to Daptomycin against MRSA.

Razieh Kebriaei, Kyle C Stamper, Katherine L Lev, Taylor Morrisette, Jacinda C Abdul-Mutakabbir, Raymond Schuch, Dario Lehoux, Michael J Rybak

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Rapid bacteriolysis ofMicrobiology spectrum · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Razieh KebriaeiAnti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
Kyle C StamperAnti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
Katherine L LevAnti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
Taylor MorrisetteAnti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
Jacinda C Abdul-MutakabbirAnti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
Raymond SchuchContraFect Corporation, Yonkers, New York, USA.ORCID 0000-0003-4324-573X
Dario LehouxContraFect Corporation, Yonkers, New York, USA.
Michael J RybakAnti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.ORCID 0000-0003-2220-0081
Eugene Applebaum College of Pharmacy and Health Sciences · USContraFect (United States) · US

Funding

MECHANISMS OF ARND RELATED SYNAPTIC PLASTICITY DEFICITSR01AA012400 · NIAAA · UNIVERSITY OF NEW MEXICO · PI SAVAGE, DANIEL DEXTER · 2000 to 2002
$658k
HHS | National Institutes of Health (NIH) R01 AI12400NIAAA NIH HHS R01 AA012400
6 · The paper itself

Abstract

Exebacase is a lysin (cell wall hydrolase) with direct lytic activity against Staphylococcus aureus including methicillin-resistant S. aureus (MRSA). Time-kill analysis experiments illustrated bactericidal activity of exebacase-daptomycin against MRSA strains MW2 and 494. Furthermore, exebacase in addition to daptomycin (10, 6, and 4 mg/kg/day) in a two-compartment

Indexed as

DaptomycinMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsEndopeptidasesMicrobial Sensitivity TestsAnti-Bacterial AgentsDaptomycinEndopeptidasesexebacasedaptomycinexebacaseS. aureus

Identifiers

PMID34398668
PMCPMC8522749
OpenAlexW3194147735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.