Evidence map›Paper›PMID 34398270›Full record

ReviewJournal of neurology2022

Interpretation of vaccine associated neurological adverse events: a methodological and historical review.

Marija Cauchi, Harriet Ball, Yoav Ben-Shlomo, Neil Robertson

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. A risk science perspective on vaccines.Risk analysis : an official publication of the Society for Risk Analysis · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Marija CauchiDivision of Psychological Medicine and Clinical Neuroscience, Department of Neurology, University Hospital of Wales, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK. cauchim1@cardiff.ac.uk.
Harriet BallPopulation Health Sciences, Bristol Medical School, Bristol, BS8 2PS, UK.
Yoav Ben-ShlomoPopulation Health Sciences, Bristol Medical School, Bristol, BS8 2PS, UK.
Neil RobertsonDivision of Psychological Medicine and Clinical Neuroscience, Department of Neurology, University Hospital of Wales, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
Cardiff University · GBUniversity Hospital of Wales · GB

Funding

Medical Research Council MR/L010305/1
6 · The paper itself

Abstract

As a result of significant recent scientific investment, the range of vaccines available for COVID-19 prevention continues to expand and uptake is increasing globally. Although initial trial safety data have been generally reassuring, a number of adverse events, including vaccine induced thrombosis and thrombocytopenia (VITT), have come to light which have the potential to undermine the success of the vaccination program. However, it can be difficult to interpret available data and put these into context and to communicate this effectively. In this review, we discuss contemporary methodologies employed to investigate possible associations between vaccination and adverse neurological outcomes and why determining causality can be challenging. We demonstrate these issues by discussing relevant historical exemplars and explore the relevance for the current pandemic and vaccination program. We also discuss challenges in understanding and communicating such risks to clinicians and the general population within the context of the 'infodemic' facilitated by the Internet and other media.

Indexed as

COVID-19VaccinesCOVID-19 VaccinesHumansInfodemicSARS-CoV-2COVID-19 VaccinesVaccinesCOVID-19Thrombosis with thrombocytopenia syndromeVaccinationVaccine-induced thrombocytosis with thrombocytopenia

Identifiers

PMID34398270
PMCPMC8366487
OpenAlexW3194945495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.