Evidence map›Paper›PMID 34398238›Full record

Observational studyThe Journal of infectious diseases2021

Preserved Mucosal-Associated Invariant T-Cell Numbers and Function in Idiopathic CD4 Lymphocytopenia.

Ornella Sortino, Joana Dias, Megan Anderson, Elizabeth Laidlaw, Edwin Leeansyah, Andrea Lisco, Virginia Sheikh, Johan K Sandberg, Irini Sereti

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00867269 (Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ Lymphocytopenia), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00867269 recruitingnot on this map

Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ Lymphocytopenia

TypeobservationalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2009Enrolled950ConditionsIdiopathic CD4+ Lymphocytopenia, Cryptococcal Meningitis, Warts
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Hitchhiker Guide to CD4Frontiers in immunology · 2021
    Pooled it
  2. Trial
  3. Article
  4. The Emerging Role of MAIT Cell Responses in Viral Infections.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ornella SortinoClinical Research Directorate/Clinical Monitoring Leidos Research Program, Leidos Biomedical Research, Inc., National Cancer Institute Campus at Frederick, Frederick, Maryland, USA.
Joana DiasCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Megan AndersonNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Elizabeth LaidlawNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Edwin LeeansyahCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Andrea LiscoNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Virginia SheikhNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Johan K SandbergCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Irini SeretiNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-0076-0224

Funding

Intestinal MAIT Cells in HIV InfectionR01DK108350 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PAQUIN-PROULX, DOMINIC, SANDBERG, JOHAN K · 2015 to 2019
$2.5M
NCI NIH HHS HHSN261200800001ENIDDK NIH HHS R01 DK108350
6 · The paper itself

Abstract

backgroundMucosal-associated invariant T (MAIT) cells constitute a subset of unconventional, MR1-restricted T cells involved in antimicrobial responses as well as inflammatory, allergic, and autoimmune diseases. Chronic infection and inflammatory disorders as well as immunodeficiencies are often associated with decline and/or dysfunction of MAIT cells.

methodsWe investigated the MAIT cells in patients with idiopathic CD4+ lymphocytopenia (ICL), a syndrome characterized by consistently low CD4 T-cell counts (<300 cell/µL) in the absence of HIV infection or other known immunodeficiency, and by susceptibility to certain opportunistic infections.

resultsThe numbers, phenotype, and function of MAIT cells in peripheral blood were preserved in ICL patients compared to healthy controls. Administration of interleukin-7 (IL-7) to ICL patients expanded the CD8+ MAIT-cell subset, with maintained responsiveness and effector functions after IL-7 treatment.

conclusionsICL patients maintain normal levels and function of MAIT cells, preserving some antibacterial responses despite the deficiency in CD4+ T cells. CLINICAL TRIALS REGISTRATION: NCT00867269.

Indexed as

LymphopeniaMucosal-Associated Invariant T CellsHIV InfectionsHumansInterleukin-7Lymphocyte CountPersistent InfectionInterleukin-7idiopathic CD4+ lymphocytopeniaIL-7MAIT cells

Identifiers

PMID34398238
PMCPMC8366440

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.