Evidence map›Paper›PMID 34397383›Full record

ArticleeLife2021

A CTP-dependent gating mechanism enables ParB spreading on DNA.

Adam Sb Jalal, Ngat T Tran, Clare Em Stevenson, Afroze Chimthanawala, Anjana Badrinarayanan, David M Lawson, Tung Bk Le

Open access · greenAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Plasmid-encoded host reprogramming promotes plasmid dissemination.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Uncovering ParB-dependent and -independent subclasses of T-dioxygenases from bacteriophage.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Expanding the diversity of bacterial DNA partitioning: A CTP-independent ParABProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 3 countries.

Adam Sb JalalDepartment of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.ORCID 0000-0001-7794-8834
Ngat T TranDepartment of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.ORCID 0000-0002-7186-3976
Clare Em StevensonDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich, United Kingdom.
Afroze ChimthanawalaNational Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.
Anjana BadrinarayananNational Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.ORCID 0000-0001-5520-2134
David M LawsonDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich, United Kingdom.ORCID 0000-0002-7637-4303
Tung Bk LeDepartment of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.ORCID 0000-0003-4764-8851
John Innes Centre · GB

Funding

Biotechnology and Biological Sciences Research Council BB/P018165/1Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9791Wellcome TrustWellcome Trust 221776/Z/20/Z
6 · The paper itself

Abstract

Proper chromosome segregation is essential in all living organisms. The ParA-ParB-

Indexed as

Bacterial ProteinsCaulobacter crescentusChromosome SegregationCrystallizationCytidine TriphosphateDNA, BacterialHydrolysisProtein BindingProtein DomainsBacterial ProteinsCytidine TriphosphateDNA, Bacterialcaulobacter crescentusCaulobacter crescentuschromosomeschromosome segregationCTPgene expressionmolecular gatesParA ParB parSspreading

Identifiers

PMID34397383
PMCPMC8367383
OpenAlexW2981959217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.