Evidence map›Paper›PMID 34397272›Full record

ReviewHypertension (Dallas, Tex. : 1979)2021

Long-Term Cardiovascular Disease Risk in Women After Hypertensive Disorders of Pregnancy: Recent Advances in Hypertension.

Kavia Khosla, Sarah Heimberger, Kristin M Nieman, Avery Tung, Sajid Shahul, Anne Cathrine Staff, Sarosh Rana

Open access · bronzeAbstract readReview
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Atherosclerosis after pre-eclampsia: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Kavia KhoslaUniversity of Chicago Pritzker School of Medicine, IL (K.K., S.H.).ORCID 0000-0003-0374-2387
Sarah HeimbergerUniversity of Chicago Pritzker School of Medicine, IL (K.K., S.H.).ORCID 0000-0001-7467-5586
Kristin M NiemanKatalyses, Ankeny, IA (K.M.N.).ORCID 0000-0001-7529-0872
Avery TungDepartment of Anesthesia and Critical Care (A.T., S.S.), University of Chicago, IL.ORCID 0000-0003-2670-0833
Sajid ShahulDepartment of Anesthesia and Critical Care (A.T., S.S.), University of Chicago, IL.ORCID 0000-0002-7477-133X
Anne Cathrine StaffInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway (A.C.S.).
Sarosh RanaDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology (S.R.), University of Chicago, IL.ORCID 0000-0002-5828-7433
University of Chicago · USIowa Soybean Association · USOslo University Hospital · NOSociety for Maternal-Fetal Medicine · US

Funding

Guideline-directed management and therapy (GDMT) for the prevention of postpartum cardiac dysfunction in preeclamptic African American womenR01HL148191 · NHLBI · UNIVERSITY OF CHICAGO · PI SHAHUL, SAJID · 2021 to 2025
$3.8M
NHLBI NIH HHS R01 HL148191
6 · The paper itself

Abstract

Patients with a history of hypertensive disorders of pregnancy (HDP) suffer higher rates of long-term cardiovascular events including heart failure, coronary artery disease, and stroke. Cardiovascular changes during pregnancy can act as a natural stress test, subsequently unmasking latent cardiovascular disease in the form of HDP. Because HDP now affect 10% of pregnancies in the United States, the American Heart Association has called for physicians who provide peripartum care to promote early identification and cardiovascular risk reduction. In this review, we discuss the epidemiology, pathophysiology, and outcomes of HDP-associated cardiovascular disease. In addition, we propose a multi-pronged approach to support cardiovascular risk reduction for women with a history of HDP. Additional research is warranted to define appropriate blood pressure targets in the postpartum period, optimize the use of pregnancy history in risk stratification tools, and clarify the effectiveness of preventive interventions. The highest rates of HDP are in populations with poor access to resources and quality health care, making it a major risk for inequity of care. Interventions to decrease long-term cardiovascular disease risk in women following HDP must also target disparity reduction.

Indexed as

Cardiovascular DiseasesEvidence-Based PracticeFemaleHealth Status DisparitiesHumansHypertension, Pregnancy-InducedPostnatal CarePregnancycardiovascular diseasehypertensionpreeclampsiapregnancyrisk factors

Identifiers

PMID34397272
PMCPMC8678921
OpenAlexW3193994659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.