ArticleAngewandte Chemie (International ed. in English)2021
Visible-Light-Driven Catalytic Deracemization of Secondary Alcohols.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Catalytic Deracemization of 1,2-Aminoalcohols through Enantioselective Hydrogen Atom Abstraction.Journal of the American Chemical Society · 2026Article
- Concurrent Linear Deracemization of Secondary Benzylic Alcohols via Simultaneous Photocatalysis and Whole-cell Biocatalysis.ACS catalysis · 2025Article
- Kinetics, Thermodynamics, and Emergence in Stereoediting Reactions.Accounts of chemical research · 2025Article
- Chiral Cobaltabis(dicarbollide) Catalysts Prepared Using a Silica Helical Nanoplatform for the Enantioselective Photooxidation of Aromatic Secondary Alcohols.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- The sugar cube: Network control and emergence in stereoediting reactions.Science (New York, N.Y.) · 2024Article
- Enantioconvergent synthesis of chiral fluorenols from racemic secondary alcoholsChemical science · 2024Article
- Non-equilibrium Steady States in Catalysis, Molecular Motors, and Supramolecular Materials: Why Networks and Language Matter.Journal of the American Chemical Society · 2023Review
- Visible Light-Mediated, Diastereoselective Epimerization of Morpholines and Piperazines to More Stable Isomers.ACS catalysis · 2022Article
- Visible-Light-Driven Catalytic Deracemization of Secondary Alcohols.Angewandte Chemie (International ed. in English) · 2021Article
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Authors and funding
2 authors.
Funding
Abstract
Deracemization of racemic chiral compounds is an attractive approach in asymmetric synthesis, but its development has been hindered by energetic and kinetic challenges. Here we describe a catalytic deracemization method for secondary benzylic alcohols which are important synthetic intermediates and end products for many industries. Driven by visible light only, this method is based on sequential photochemical dehydrogenation followed by enantioselective thermal hydrogenation. The combination of a heterogeneous dehydrogenation photocatalyst and a chiral molecular hydrogenation catalyst is essential to ensure two distinct pathways for the forward and reverse reactions. These reactions convert a large number of racemic aryl alkyl alcohols into their enantiomerically enriched forms in good yields and enantioselectivities.
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